亚抑菌浓度抗菌药物影响金黄色葡萄球菌生物膜形成的研究进展OA北大核心CSTPCD

Staphylococcus aureus(SA)is one of the common pathogens causing healthcare-associated infection,which easily adheres to the surface of catheters or implants to form biofilm,leading to increased antimicrobial resis-tance,and posing great challenge to clinical treatment.In recent years,studies have shown that antimicrobial agents at sub-minimum inhibitory concentration(sub-MIC)can affect the biofilm formation of SA.This paper elaborates the formation process and gene regulation of SA biofilm,as well as the effect and mechanisms of different antimicro-bial agents at sub-MIC on SA biofilm formation,so as to provide basis for effective control and treatment of SA bio-film-related infection.