中国临床医学2024，Vol.31Issue(2)：186-191,6.DOI:10.12025/j.issn.1008-6358.2024.20231977
天冬氨酸氨基转移酶与血小板比值指数与纤维化-4指数对肝癌切除术后患者预后的预测价值
The predictive value of aspartate aminotransferase-to-platelet ratio index and fibrosis-4 index for the prognosis of patients with hepatocellular carcinoma after resection
摘要
Abstract
Objective To explore whether liver cirrhosis markers aspartate aminotransferase-to-platelet ratio index(APRI)and fibrosis-4 index(FIB-4)based on blood biochemical indicators can predict disease free survival(DFS)and overall survival(OS)in patients with hepatocellular carcinoma(HCC)after resection.Methods 300 patients with HCC who underwent radical resection in Zhongshan Hospital,Fudan University from February 2005 to July 2017 were enrolled and the clinicopathological characteristics,recurrence and survival of these patients were retrospectively collected.The relationships between APRI,FIB-4 and postoperative recurrence and survival were evaluated.The ROC curve was used to evaluate the predictive values of APRI,FIB-4.Results The median follow-up of 300 patients was 61 months.Univariate Cox regression analysis showed that APRI,FIB-4,vascular invasion were risk factors affecting postoperative DFS and OS.The multivariate Cox regression analysis showed that vascular invasion was the independent risk factor for postoperative DFS(HR=1.518,95%CI 1.024-2.252,P=0.038)and OS(HR=2.301,95%CI 1.270-4.167,P=0.006).The time dependent ROC(time-ROC)curve showed that AUCs of APRI and FIB-4 predicting 1-year,3-year,and 5-year DFS were 0.555-0.596,which were 0.600-0.679 when predicting 1-year,3-year,and 5-year OS.Conclusions The predictive value of APRI and FIB-4 based on blood biochemical indicators alone for postoperative DFS and OS in HCC patients is limited.关键词
肝细胞癌/预后/天冬氨酸氨基转移酶与血小板比值指数/纤维化-4指数Key words
hepatocellular carcinoma/prognosis/aspartate aminotransferase-to-platelet ratio index/fibrosis-4 index分类
医药卫生引用本文复制引用
李曹杰,李嘉浚,徐叶,陈茂培,罗剑锋,任正刚,杨欣荣,陈荣新..天冬氨酸氨基转移酶与血小板比值指数与纤维化-4指数对肝癌切除术后患者预后的预测价值[J].中国临床医学,2024,31(2):186-191,6.基金项目
国家自然科学基金(81972715).Supported by National Natural Science Foundation of China(81972715). （81972715）
