中国临床医学2024，Vol.31Issue(2)：215-220,6.DOI:10.12025/j.issn.1008-6358.2024.20240155
血清FGF23、Klotho蛋白与维持性血液透析患者心脏瓣膜钙化的相关性
Study on the correlation between serum FGF23,Klotho protein levels and cardiac valve calcification in maintenance hemodialysis patients
摘要
Abstract
Objective To explore the correlation between serum fibroblast growth factor-23(FGF23),Klotho protein levels and cardiac valve calcification(CVC)in patients with maintenance hemodialysis(MHD).Methods A total of 169 MHD patients in the Blood Purification Center of Jinshan Hospital,Fudan University from January 2022 to January 2023 were selected.The patients'CVC status was examined by color Doppler echocardiography.Results There were 111 CVC cases,accounting for 65.68%.Compared with the non-CVC group,the CVC group had significantly higher levels of FGF23,β2-microglobulin,brain natriuretic peptide(BNP),age,and the proportion of male,while significantly lower levels of Klotho,predialysis creatinine,hemoglobin,plasma albumin and iPTH(P＜0.05).Pearson/Spearman correlation coefficient analysis showed that FGF23,age,β2-microglobulin and BNP were significantly positively correlated with CVC(r=0.20,0.41,0.15,0.28,0.12),while Klotho,predialysis creatinine,hemoglobin,plasma albumin and iPTH were significantly negatively correlated with CVC(r=﹣0.16,﹣0.17,﹣0.16,﹣0.17,﹣0.16).Unconditioned binary logistic regression analysis showed that FGF23,Klotho,age and β2-microglobulin were independent risk factors for CVC in MHD patients.Conclusions MHD patients are prone to CVC.Serum FGF23 protein level is significantly positively correlated with CVC,while Klotho protein level is significantly negatively correlated with CVC.FGF23,Klotho,age and β2-microglobulin are independent risk factors for CVC in MHD patients.关键词
维持性血液透析/心脏瓣膜钙化/成纤维细胞生长因子23/Klotho蛋白Key words
maintenance hemodialysis/cardiac valve calcification/fibroblast growth factor-23/Klotho protein分类
医药卫生引用本文复制引用
何正佳,王娇,王成军,鲍晓荣..血清FGF23、Klotho蛋白与维持性血液透析患者心脏瓣膜钙化的相关性[J].中国临床医学,2024,31(2):215-220,6.基金项目
上海市金山区医药卫生类科技创新资金项目(2020-3-23).Supported by Medical and Health Technology Innovation Fund Project of Jinshan District,Shanghai(2020-3-23). （2020-3-23）
