中国美容医学2024，Vol.33Issue(4)：191-194,4.
人NK细胞亚群的生物学变化与机体衰老的关系
The Biological Changes of Human NK Cell Subsets and Their Relationship with Aging
秦红 1邹霓霞 1王启华1
作者信息
- 1. 湖南爱备康健康科技有限公司 湖南长沙 410205
- 折叠
摘要
Abstract
Natural kill cells(NK cells)is a kind of innate immune lymphoid cells(ILP),which is the third major type of lymphocyte besides T cells and B cells.It is characterized by rapid reaction without antigen sensitization to produce non-specific killing effect.NK cells induce apoptosis of target cells by secreting perforin,granzyme,cytokines and chemokines,and can also express Fc receptor(CD 16),which mediates antibody-dependent cell-mediated cytotoxicity(ADCC).With aging,the function of the immune system decreases,and NK cells initiate adaptive immune response disorders,which cannot mobilize effective immune responses and other physiological phenomena,leading to the occurrence of aging-related diseases such as infection and tumor.In this paper,the biological changes of NK Cells Subsets in the whole life cycle are discussed to explore the relationship between NK cells and aging,so as to lay a foundation for the clinical application of NK cells.关键词
NK细胞亚群/衰老/免疫反应/感染/肿瘤Key words
NK cells subsets/aging/immune response/infection/tumor分类
医药卫生引用本文复制引用
秦红,邹霓霞,王启华..人NK细胞亚群的生物学变化与机体衰老的关系[J].中国美容医学,2024,33(4):191-194,4.
