中国现代医学杂志2024，Vol.34Issue(8)：9-14,6.DOI:10.3969/j.issn.1005-8982.2024.08.002
超声实时剪切波弹性成像、血清透明质酸对非酒精性脂肪性肝病的诊断价值
Diagnostic value of real-time shear wave ultrasound elastography combined with serum hyaluronic acid for non-alcoholic fatty liver disease
摘要
Abstract
Objective To explore the diagnostic value of real-time shear wave ultrasound elastography combined with serum fibrosis marker hyaluronic acid for non-alcoholic fatty liver disease.Methods From April 2020 to April 2023,the 112 patients with non-alcoholic fatty liver disease treated in the Affiliated Xuancheng Hospital of Wannan Medical College were selected as the liver disease group.Additionally,112 healthy individuals with normal liver function who underwent health checkup in the hospital during the same period were selected as the control group.Medical records of all participants were collected,and all of them underwent real-time shear wave ultrasound elastography and were tested for serum hyaluronic acid.The diagnosis of non-alcoholic fatty liver disease was confirmed by liver tissue biopsy as the gold standard.The Young's modulus values and the serum levels of hyaluronic acid were compared between the two groups.The diagnostic performance of real-time shear wave ultrasound elastography and serum hyaluronic acid for non-alcoholic fatty liver disease was evaluated.Results The levels of hyaluronic acid,ALT and AST in the liver disease group were higher than those in the control group(P<0.05),and Young's modulus values in the liver disease group were higher than those in the control group(P<0.05).Multivariable stepwise Logistic regression analysis revealed that low Young's modulus value[O^R = 4.627(95%CI:1.627,13.159)]was a protective factor for non-alcoholic fatty liver disease,and that high levels of hyaluronic acid[O^R = 4.116(95%CI:1.924,8.807)],ALT[O^R = 3.691(95%CI:1.725,7.898)]and AST[O^R = 3.846(95%CI:1.798,8.229)]were risk factors for non-alcoholic fatty liver disease(P<0.05).The receiver operating characteristic analysis demonstrated that the sensitivities of the Young's modulus value and the serum level of hyaluronic acid alone and their combination for diagnosing non-alcoholic fatty liver disease were 68.9%(95%CI:0.591,0.752),76.2%(95%CI:0.695,0.843)and 84.3%(95%CI:0.726,0.935),with the specificities being 83.1%(95%CI:0.723,0.921),68.4%(95%CI:0.571,0.794)and 83.5%(95%CI:0.719,0.926).Conclusion Real-time shear wave ultrasound elastography combined with serum hyaluronic acid could assist the diagnosis of non-alcoholic fatty liver disease with good diagnostic performance.关键词
非酒精性脂肪性肝病/超声实时剪切波弹性成像/透明质酸/诊断Key words
non-alcoholic fatty liver disease/real-time shear wave ultrasound elastography/hyaluronic acid/diagnosis分类
医药卫生引用本文复制引用
郑伟伟,俞慧,郑慧..超声实时剪切波弹性成像、血清透明质酸对非酒精性脂肪性肝病的诊断价值[J].中国现代医学杂志,2024,34(8):9-14,6.基金项目
安徽省自然科学基金青年基金(No:2208085QH261) （No:2208085QH261）
