中国现代医学杂志2024，Vol.34Issue(8)：34-39,6.DOI:10.3969/j.issn.1005-8982.2024.08.006
腺苷酸活化蛋白激酶在炎症性肠病的研究进展
Research progress of AMP-activated protein kinase in inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease is a chronic inflammatory and immune-related intestinal disease and represents a major global health challenge with its incidence being on the rise year by year.However,the exact pathogenesis of inflammatory bowel disease is still not well understood.AMP-activated protein kinase(AMPK)is a highly conserved cellular energy sensor that plays a crucial role in maintaining energy balance within the body.In recent years,studies have found that AMPK can slow down the progression of inflammatory bowel disease by enhancing intestinal barrier function,inhibiting inflammatory responses,exerting anti-fibrosis effects,and promoting autophagy.This review will explore the aforementioned perspectives,with the aim of providing novel insights into therapeutic targets for inflammatory bowel disease.关键词
炎症性肠病/腺苷酸活化蛋白激酶/结肠炎Key words
inflammatory bowel disease/AMP-activated protein kinase/colitis分类
医药卫生引用本文复制引用
王裕倩,蓝程,符永华,王新月..腺苷酸活化蛋白激酶在炎症性肠病的研究进展[J].中国现代医学杂志,2024,34(8):34-39,6.基金项目
国家自然科学基金(No:82060102,No:81860102) （No:82060102,No:81860102）
海南省自然科学基金(No:821RC1116) （No:821RC1116）
海南省卫生健康行业科研项目(No:20A200066) （No:20A200066）
