中国现代医学杂志2024，Vol.34Issue(8)：65-69,5.DOI:10.3969/j.issn.1005-8982.2024.08.011
同步放化疗联合早期综合营养治疗在局部晚期鼻咽癌中的应用价值
Application value of concurrent chemoradiotherapy combined with early comprehensive nutritional therapy in patients with locally advanced nasopharyngeal carcinoma
摘要
Abstract
Objective To analyze the value of concurrent chemoradiotherapy combined with early comprehensive nutritional therapy in the treatment of locally advanced nasopharyngeal carcinoma.Methods A total of 100 patients with locally advanced nasopharyngeal carcinoma in our hospital from January 2018 to December 2020 were retrospectively analyzed.The patients were divided into the control group(n = 50)and the observation group(n = 50)according to the intervention methods.The control group was treated with concurrent chemoradiotherapy and given conventional nutritional support,while the observation group received concurrent chemoradiotherapy combined with early comprehensive nutritional therapy.The nutrition knowledge,the nutritional status and immune function before and after intervention,and the long-term efficacy were compared between the groups.Results The scores of nutrition knowledge,appetite,function and dietary adherence in the observation group were higher than those in the control group(P<0.05).The differences of the levels of blood albumin and hemoglobin before and after treatment in the observation group were higher than those in the control group(P<0.05).The difference of the level of transferrin before and after treatment was not different between the two groups(P>0.05).The differences of levels of CD3+ and CD4+ cells and the ratio of CD4+/CD8+ cells before and after treatment in the observation group were higher than those in the control group(P<0.05).The difference of the level of CD8+ cells before and after treatment was not different between the two groups(P>0.05).The overall survival rate,disease-specific survival rate,local recurrence-free rate and distant metastasis-free survival rate of the observation group were significantly higher than those of the control group(P<0.05).Conclusion For patients with locally advanced nasopharyngeal carcinoma,concurrent chemoradiotherapy combined with early comprehensive nutritional therapy enhances their nutrition knowledge,reduces the impact of the disease on nutritional status and immune function,and significantly improves the prognosis of patients.关键词
局部晚期鼻咽癌/同步放化疗/早期综合营养治疗/营养状态/免疫功能Key words
locally advanced nasopharyngeal carcinoma/concurrent chemoradiotherapy/early comprehensive nutritional therapy/nutritional status/immune function分类
医药卫生引用本文复制引用
刘新菊,刘冬梅,邱荣良..同步放化疗联合早期综合营养治疗在局部晚期鼻咽癌中的应用价值[J].中国现代医学杂志,2024,34(8):65-69,5.基金项目
河南省科技计划项目(No:202102310114) （No:202102310114）
