中国药房2024，Vol.35Issue(8)：1023-1028,6.DOI:10.6039/j.issn.1001-0408.2024.08.22
骨碎补活性成分促进骨缺损后骨重建的机制及其组织工程学应用
Mechanism and application in tissue engineering of the active ingredient of Drynariae Rhizoma promoting bone defect repair
摘要
Abstract
Bone defect has always been a major clinical challenge because of its great difficulty and long period of treatment.Drynariae Rhizoma is a commonly used medicine in osteology and traumatology of traditional Chinese medicine,and its active ingredients(mainly flavonoids)facilitate osteoblast differentiation of bone marrow mesenchymal stem cells,osteoclast proliferation,vascular-osteogenic coupling,and inhibit osteoclast activity to promote bone mineralization,and repair and reconstruction of bone defect.As a good substitute for bone regeneration drugs,the active constituents of Drynariae Rhizoma can be loaded on scaffold materials of tissue engineering,which greatly improves the bioavailability of the drug.Meanwhile,the sustained-release microspheres also solve some problems such as sudden drug release from the scaffolds,and the composite scaffolds with active ingredient of Drynariae Rhizoma prepared by them have good ossification activity and osteoinduction,with precise bone repair effects,which meet the diverse performance requirements of bone grafts and have a promising clinical application prospect.关键词
骨碎补/活性成分/总黄酮/骨缺损/骨组织工程Key words
Drynariae Rhizoma/active ingredient/total flavonoids/bone defect/bone tissue engineering分类
医药卫生引用本文复制引用
邓志军,杨文龙,杨智军,赵斌,李典,杨凤云..骨碎补活性成分促进骨缺损后骨重建的机制及其组织工程学应用[J].中国药房,2024,35(8):1023-1028,6.基金项目
全国名老中医药专家传承工作室建设项目(No.国中医药人教函[2022]75号) （No.国中医药人教函[2022]75号）
江西省省级科技计划项目(No.20212-BCG74004) （No.20212-BCG74004）
江西省中医药管理局重点研究室、临床研究基地建设项目(No.赣中医药科教字[2020]6号) （No.赣中医药科教字[2020]6号）
江西省研究生创新专项资金项目(No.YC2022-s876) （No.YC2022-s876）
江西中医药大学"大学生创新创业训练计划"项目(No.X202310412165) （No.X202310412165）
