血清Toll样受体9与创伤致脓毒症患者预后的关系OA北大核心CSTPCD

Objective To investigate the relationship between serum Toll-like receptor 9(TLR9)levels and the prognosis of patients with sepsis caused by trauma.Methods Fifty-three patients with post-traumatic sepsis(sepsis group),208 patients without sepsis(non-sepsis group),and 63 physical examination volunteers(control group)treated at the Chongqing Emergency Medical Center from August 2020 to August 2022 were selected.Serum TLR9 levels in trauma patients were detected at 1 h(T0),3 h(T1),6 h(T2),12 h(T3),24 h(T4),48 h(T5),and 72 h(T6)after admission(day of physical examination in the control group).The risk factors for nosocomial death in patients with trauma-induced sepsis and the value of TLR9 in predicting nosocomial death were analyzed.Results The serum TLR9 level in the sepsis and non-sepsis groups at T0 was higher than that in the control group(P<0.05).The serum TLR9 level at T1 to T6 in the sepsis group was higher than that in the non-sepsis group(P<0.05).The serum TLR9 level of T4 to T6 in the death group was higher than that in the survival group(P<0.05).A baseline SOFA score≥17 and TLR9 level at T6 time point≥3 pg/mL were risk factors for nosocomial death in patients with sepsis caused by trauma(P<0.05).The areas under the curve of TLR9 level at T6 time point,baseline SOFA score,and their combined prediction of in-hospital mortality in patients with trauma-induced sepsis were 0.719,0.754,and 0.824,respectively.Conclusion Serum TLR9 levels were significantly increased in patients with trauma-induced sepsis,which is associated with nosocomial death and can be used as an auxiliary indicator for prognosis assessment.