中国药理学通报2024，Vol.40Issue(4)：606-611,6.DOI:10.12360/CPB202304079
硝化应激在肺动脉高压中的研究进展
Recent advances of nitrative stress in pulmonary hypertension
摘要
Abstract
Pulmonary hypertension(PH)is a progressive pul-monary vascular disease characterized by endothelial dysfunc-tion,inappropriate smooth muscle cell proliferation,inflammatory and fibrosis.The mechanism of PH remains unclear,but nitra-tive stress has been shown to play an important role in PH.This chapter reviews the sources of reactive nitrogen species(RNS)in pulmonary circulation,and the role of nitrative stress in the de-velopment and occurrence of PH,so as to provide reference for the clinical application of targeted anti-nitrification therapy.关键词
肺动脉高压/活性氮/硝化应激/一氧化氮/内皮细胞/一氧化氮合酶/小窝蛋白-1Key words
pulmonary hypertension/reactive nitrogen species/nitrative stress/nitric oxide/endothelial cells/nitric oxide syn-thase/caveolin-1分类
医药卫生引用本文复制引用
冀磊,杨进,芦殿香..硝化应激在肺动脉高压中的研究进展[J].中国药理学通报,2024,40(4):606-611,6.基金项目
国家自然科学基金项目(No 82374148,82060786) （No 82374148,82060786）
青海省科技厅自然科学基金面上项目(No 2021-ZJ-907) （No 2021-ZJ-907）
