硝化应激在肺动脉高压中的研究进展OA北大核心CSTPCD
Recent advances of nitrative stress in pulmonary hypertension
肺动脉高压(pulmonary hypertension,PH)是一种进行性发展的肺血管疾病,病理基础包括内皮功能障碍、平滑肌细胞异常增生、炎症浸润以及肺纤维化.PH的发生机制尚不完全清楚,但硝化应激已经证实在PH中发挥了重要作用.该文综述了活性氮(reactive nitrogen species,RNS)的种类及肺循环中RNS的来源,以及由此引发的硝化应激在PH发生发展中的作用,以期为靶向抗硝化治疗的临床应用提供参考依据.
Pulmonary hypertension(PH)is a progressive pul-monary vascular disease characterized by endothelial dysfunc-tion,inappropriate smooth muscle cell proliferation,inflammatory and fibrosis.The mechanism of PH remains unclear,but nitra-tive stress has been shown to play an important role in PH.This chapter reviews the sources of reactive nitrogen species(RNS)in pulmonary circulation,and the role of nitrative stress in the de-velopment and occurrence of PH,so as to provide reference for the clinical application of targeted anti-nitrification therapy.
冀磊;杨进;芦殿香
青海省人民医院,青海西宁 810007成都大学附属医院,四川成都 610081
基础医学
肺动脉高压活性氮硝化应激一氧化氮内皮细胞一氧化氮合酶小窝蛋白-1
pulmonary hypertensionreactive nitrogen speciesnitrative stressnitric oxideendothelial cellsnitric oxide syn-thasecaveolin-1
《中国药理学通报》 2024 (004)
藏药三味檀香散保护低氧性肺动脉高压大鼠右心室结构和功能的物质基础及作用机制
606-611 / 6
国家自然科学基金项目(No 82374148,82060786);青海省科技厅自然科学基金面上项目(No 2021-ZJ-907)
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