中国药理学通报2024，Vol.40Issue(4)：611-618,8.DOI:10.12360/CPB202206050
干扰素基因刺激因子激动剂的研究进展
Research progress of STING agonists
摘要
Abstract
As an important part of the innate immune system,the cGAS-STING pathway can recognize cytoplasmic DNA from pathogenic microorganisms and host cells,induce the secretion of type Ⅰ interferon and the production of inflammatory cytokines,activate the immune system,resist the invasion of pathogenic mi-croorganisms,and enhance antitumor activity.Here we briefly introduce the mechanism and biological functions of the cGAS-STING pathway,focus on the current research progress of STING agonists,including the pharmacological effects and research sta-ges of STING CDN and Non-CDN agonists,and finally summari-zes and prospects the problems and challenges in the research of STING agonists,in order to provide ideas for the development of related drugs and disease treatment.关键词
cGAS-STING通路/免疫应答/STING激动剂/Ⅰ型干扰素/抗肿瘤免疫/抗感染免疫Key words
cGAS-STING pathway/immune response/STING agonists/type Ⅰ interferon/antitumor immunity/anti-infection immunity分类
医药卫生引用本文复制引用
王娅,吴硕,李玉环..干扰素基因刺激因子激动剂的研究进展[J].中国药理学通报,2024,40(4):611-618,8.基金项目
国家自然科学基金青年项目(No 81803592) （No 81803592）
中国医学科学院医学与健康科技创新工程项目(No 2021-1-I2M-030) （No 2021-1-I2M-030）
