中国药理学通报2024，Vol.40Issue(4)：625-629,5.DOI:10.12360/CPB202211079
铁死亡在骨代谢中的调控机制
The regulatory mechanism of ferroptosis in bone metabolism
摘要
Abstract
Ferroptosis is a novel mode of cell death characterized by intracellular iron overload and excessive accumulation of lipid peroxides,which is closely associated with the pathogenesis of many orthopedic diseases.Osteoporosis is a chronic metabolic bone disease characterized by decreased bone mineral density.In recent years,a large number of studies have been conducted to regulate bone homeostasis through ferroptosis to treat osteopo-rosis,and certain results have been obtained,showing a good research prospect.This article summarizes the mechanism and regulation pathway of ferroptosis,explores the correlation be-tween ferroptosis and the pathological mechanism of osteoporo-sis,systematically elaborates on the effect of ferroptosis in osteo-blasts,osteoclasts and bone marrow mesenchymal stem cells,and sorts out the therapeutic application of ferroptosis for osteo-porosis in order to expand the therapeutic ideas of osteoporosis.关键词
骨质疏松症/铁死亡/铁过载/病理机制/骨代谢/程序性死亡Key words
ferroptosis/osteoporosis/iron overload/patho-mechanism/Bone metabolism/programmed death分类
医药卫生引用本文复制引用
文皓楠,王凯,海云翔,董万涛,宋志靖,宋敏..铁死亡在骨代谢中的调控机制[J].中国药理学通报,2024,40(4):625-629,5.基金项目
国家自然科学基金地区项目(No 81960877,81960878) （No 81960877,81960878）
甘肃省高等学校产业支撑计划项目(No 2022CYZC-52) （No 2022CYZC-52）
