中国药理学与毒理学杂志2024，Vol.38Issue(4)：241-248,8.DOI:10.3867/j.issn.1000-3002.2024.04.001
阿伦狄克酸对脑缺血再灌注损伤食蟹猴模型的神经保护作用
Neuroprotective effect of arundic acid on Cynomolgus macaques with cerebral ischemia-reperfusion injury
王向伟 1付立杰 1周永馨 1庄永杰 1陈继巧 1毛佳静 1周静 1邓志豪 1邢柳柳 1周业明1
作者信息
- 1. 布瑞迅药业(南通)有限公司,江苏 南通 226133
- 折叠
摘要
Abstract
OBJECTIVE To evaluate the therapeutic effect of arundic acid against cerebral ischemia-reperfusion injury(CIRI)Cynomolgus macaques.METHODS Nine healthy male cynomolgus monkeys were subjected to 4 h ligation of the left middle cerebral artery followed by reperfusion before they were randomly divided into model,model+calcium arundate 10 and 30 mg·kg-1 groups,with three cynomolgus monkeys in each.72 h post-cerebral infarction,the three groups were orally administrated with viehcles[20%(W:V)Solutol HS15 and 10%(V:V)PEG 400]or calcium arundate 10 and 30 mg·kg-1 twice daily for 28 consecutive days,respectively.Neurological impairment and recovery were assessed by a series of neurobehavioral tests,such as upper extremity feeding skill tests and observation of animal cage behaviour,as well as magnetic resonance data of cerebral infarction volume and cerebral edema volume during treatment.RESULTS The model group showed natural spontaneous recovery after the middle cerebral artery occlusion.After treatment with calcium arundate 30 mg·kg-1 twice daily,a remarkable neurological function recovery in terms of behavior,upper limb activity,and brain lesion volume was observed(P＜0.05).Meanwhile,calcium arundate 10 mg·kg-1 group did not show convincing improve-ment in comparison with the model group.CONCLUSION Arundic acid can reduce the volume of the infarct area,improve neurobehavioral activities,and skeletal muscle coordination function in the Cyno-molgus macaques model of CIRI.Arundic acid has the potential to be an effective neuroprotective agent in cerebral ischemia stroke.关键词
阿伦狄克酸/脑缺血再灌注损伤/神经行为学/食蟹猴Key words
arundic acid/cerebral ischemia-reperfusion injury/neurobehavior/Cynomolgus macaques分类
医药卫生引用本文复制引用
王向伟,付立杰,周永馨,庄永杰,陈继巧,毛佳静,周静,邓志豪,邢柳柳,周业明..阿伦狄克酸对脑缺血再灌注损伤食蟹猴模型的神经保护作用[J].中国药理学与毒理学杂志,2024,38(4):241-248,8.
