阿伦狄克酸对脑缺血再灌注损伤食蟹猴模型的神经保护作用OA北大核心CSTPCD

OBJECTIVE To evaluate the therapeutic effect of arundic acid against cerebral ischemia-reperfusion injury(CIRI)Cynomolgus macaques.METHODS Nine healthy male cynomolgus monkeys were subjected to 4 h ligation of the left middle cerebral artery followed by reperfusion before they were randomly divided into model,model+calcium arundate 10 and 30 mg·kg-1 groups,with three cynomolgus monkeys in each.72 h post-cerebral infarction,the three groups were orally administrated with viehcles[20%(W:V)Solutol HS15 and 10%(V:V)PEG 400]or calcium arundate 10 and 30 mg·kg-1 twice daily for 28 consecutive days,respectively.Neurological impairment and recovery were assessed by a series of neurobehavioral tests,such as upper extremity feeding skill tests and observation of animal cage behaviour,as well as magnetic resonance data of cerebral infarction volume and cerebral edema volume during treatment.RESULTS The model group showed natural spontaneous recovery after the middle cerebral artery occlusion.After treatment with calcium arundate 30 mg·kg-1 twice daily,a remarkable neurological function recovery in terms of behavior,upper limb activity,and brain lesion volume was observed(P＜0.05).Meanwhile,calcium arundate 10 mg·kg-1 group did not show convincing improve-ment in comparison with the model group.CONCLUSION Arundic acid can reduce the volume of the infarct area,improve neurobehavioral activities,and skeletal muscle coordination function in the Cyno-molgus macaques model of CIRI.Arundic acid has the potential to be an effective neuroprotective agent in cerebral ischemia stroke.