摘要
Abstract
Objective:To investigate the effect of immunomodulators combined with Compound Ipratropium Bromide Solution for Inhalation in the treatment of chronic obstructive pulmonary disease(COPD).Method:A total of eighty COPD patients who were treated in the Respiratory Department of Shandong Qingzhou Rongjun Hospital from January 2017 to January 2019 were selected,they were divided into a control group(Compound Ipratropium Bromide Solution for Inhalation)and an observation group(combined with immunomodulators)by random number table method,with 40 cases in each group.The clinical efficacy,inflammatory factors[high-sensitivity C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)],lung function[peak expiratory flow(PEF),maximal voluntary ventilation(MVV),forced expiratory volume at 1 second to predicted value(FEV1%pred)],airway mucus hypersensitivity[Toll like receptor 4(TLR4),sputum wet dry density,mucin 5AC(MUC5AC)]and incidence of adverse reactions of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in inflammatory factors between the two groups(P>0.05);after treatment,hs-CRP,TNF-α and PCT of the two groups were decreased compared to those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in lung function indicators between the two groups(P>0.05);after treatment,PEF,MVV,and FEV1%pred in both groups were increased compared to those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the high secretion of airway mucus between the two groups(P>0.05);after treatment,TLR4 in both groups were decreased,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05),the dry wet ratio of sputum and MUC5AC were decreased,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:The combination of immunomodulators and Compound Ipratropium Bromide Solution for Inhalation is effective in treating COPD.It can improve lung function,inhibit inflammatory reactions,alleviate airway mucus hypersensitivity,and has high safety.关键词
免疫调节剂/复方异丙托溴铵溶液/雾化治疗/慢性阻塞性肺疾病/肺功能/气道黏液高分泌/炎症因子Key words
Immunomodulators/Compound Ipratropium Bromide Solution/Nebulizer therapy/Chronic obstructive pulmonary disease/Lung function/Airway mucus hypersecretion/Inflammatory factors
