中国医学创新2024，Vol.21Issue(9)：129-133,5.DOI:10.3969/j.issn.1674-4985.2024.09.029
氟替美维吸入粉雾剂联合小剂量阿奇霉素用于老年AECOPD患者肺康复治疗中的临床观察
Clinical Observation of Flutemevir Powder Inhalation Combined with Low-dose Azithromycin for Pulmonary Rehabilitation Treatment in Elderly Patients with AECOPD
摘要
Abstract
Objective:To explore the clinical effect of Flutemevir Powder Inhalation combined with low-dose Azithromycin for pulmonary rehabilitation treatment in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:A total of 80 elderly patients with AECOPD admitted to Respiratory Department of Pingxiang People's Hospital were enrolled as the research objects from January 2021 to June 2023,they were divided into control group(40 cases)and study group(40 cases)by random number table method.Both groups received treatment after their condition stabilized.Control group was given Flutemevir Powder Inhalation,while study group was additionally given low-dose Azithromycin.All were treated for 1 month.The inflammatory indexes[C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)],pulmonary function[forced exhalation volume for 1 second(FEV1),forced vital capacity(FVC),FEV1/FVC%],scores of COPD assessment test(CAT)and St.George's respiratory questionnaire(SGRQ)and incidence of adverse reactions were compared between the two groups.Result:After treatment,levels of CRP,IL-6 and TNF-α were decreased,while levels of FEV1,FVC and FEV1/FVC%were increased in both groups,and the improvement of inflammatory indexes and pulmonary function in study group were better than those in the control group(P<0.05).After treatment,scores of CAT and SGRQ in both groups were decreased,those in study group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application effect of Flutemevir Powder Inhalation combined with low-dose Azithromycin is significant in pulmonary rehabilitation treatment of elderly patients with AECOPD,which can effectively reduce levels of inflammatory indexes,improve pulmonary function,respiratory symptoms and quality of life.关键词
氟替美维吸入粉雾剂/阿奇霉素/老年/急性加重期/慢性阻塞性肺疾病/肺康复Key words
Flutemevir Powder Inhalation/Azithromycin/Elderly/Acute exacerbation/Chronic obstructive pulmonary disease/Pulmonary rehabilitation引用本文复制引用
刘平香,董利民,沈湘波..氟替美维吸入粉雾剂联合小剂量阿奇霉素用于老年AECOPD患者肺康复治疗中的临床观察[J].中国医学创新,2024,21(9):129-133,5.基金项目
萍乡市科技计划项目(2020PY010) （2020PY010）
