中国医学科学院学报2024，Vol.46Issue(2)：147-153,7.DOI:10.3881/j.issn.1000-503X.15717
基于机器学习分析的浸润性乳腺癌蛋白质编码基因的标志物鉴定
Identification of Protein-Coding Gene Markers in Breast Invasive Carcinoma Based on Machine Learning
摘要
Abstract
Objective To screen out the biomarkers linked to prognosis of breast invasive carcinoma based on the analysis of transcriptome data by random forest(RF),extreme gradient boosting(XGBoost),light gradient boosting machine(LightGBM),and categorical boosting(CatBoost).Methods We obtained the ex-pression data of breast invasive carcinoma from The Cancer Genome Atlas and employed DESeq2,t-test,and Cox univariate analysis to identify the differentially expressed protein-coding genes associated with survival prog-nosis in human breast invasive carcinoma samples.Furthermore,RF,XGBoost,LightGBM,and CatBoost mod-els were established to mine the protein-coding gene markers related to the prognosis of breast invasive cancer and the model performance was compared.The expression data of breast cancer from the Gene Expression Omnibus was used for validation.Results A total of 151 differentially expressed protein-coding genes related to survival prog-nosis were screened out.The machine learning model established with C3orf80,UGP2,and SPC25 demonstrated the best performance.Conclusions Three protein-coding genes(UGP2,C3orf80,and SPC25)were screened out to identify breast invasive carcinoma.This study provides a new direction for the treatment and diagnosis of breast invasive carcinoma.关键词
浸润性乳腺癌/生物标志物/蛋白质编码基因/UGP2/C3orf80/SPC25Key words
breast invasive carcinoma/biomarker/protein-coding genes/UGP2/C3orf80/SPC25分类
医药卫生引用本文复制引用
武乐,闵开元,柳江枫,梁万丰,杨晔宏,胡刚,杨俊涛..基于机器学习分析的浸润性乳腺癌蛋白质编码基因的标志物鉴定[J].中国医学科学院学报,2024,46(2):147-153,7.基金项目
国家自然科学基金(31970649)和中国医学科学院医学与健康科技创新工程(CIFMS2021-I2M-1-057、CIFMS2021-12M-1-001) （31970649）
