中国肿瘤外科杂志2024，Vol.16Issue(2)：196-200,5.DOI:10.3969/j.issn.1674-4136.2024.02.017
未分化甲状腺癌去分化过程的分子研究进展
Advances in the Molecular Research on the Dedefferentiation Process of Anaplastic Thyroid Cancer
摘要
Abstract
Anaplastic thyroid cancer(ATC)is a rare but extremely aggressive form of thyroid cancer that is fatal to most patients.With the regularization of molecular testing and the continuous development of molecular targeted drugs,molecular targeted therapy has become an important treatment method for anaplastic thyroid cancer.However,there is extensive heterogeneity in the molecular and genetic characteristics of ATC,which makes targeted therapy of ATC more difficult.Many studies have proven that ATC originates from differentiated thyroid carcinoma(DTC)and triggers the dedifferentiation process through specific molecular events.However,the molecular mechanism that triggers this process and maintains the invasiveness of ATC is not fully understood.This article discusses the molecular evolutionary trajectory from DTC to ATC and reviews the relevant molecular mechanisms,which has guiding significance for the diagnosis and treatment of anaplastic thyroid cancer.关键词
甲状腺癌/未分化甲状腺癌/分化型甲状腺癌/分子机制/靶向治疗Key words
Thyroid cancer/Anaplastic thyroid cancer/Differentiated thyroid cancer/Molecular mechanism/Targeted therapy引用本文复制引用
王帅,王宽宇,孔祥定,李承..未分化甲状腺癌去分化过程的分子研究进展[J].中国肿瘤外科杂志,2024,16(2):196-200,5.基金项目
黑龙江省卫生健康委科技计划(20220404010995) （20220404010995）
