中国医学装备2024，Vol.21Issue(4)：13-17,5.DOI:10.3969/j.issn.1672-8270.2024.04.003
适形调强放射治疗联合经动脉化疗栓塞治疗晚期肝细胞癌的预后研究
Prognostic study of IMRT combined with TACE for advanced hepatocellular carcinoma
王鸿飞 1杨柳 2周解平 2吴爱东3
作者信息
- 1. 安徽省肿瘤医院放疗科 合肥 230031||合肥工业大学汽车与交通工程学院 合肥 230031
- 2. 安徽省肿瘤医院放疗科 合肥 230031
- 3. 中国科学技术大学附属第一医院放疗科 合肥 230031
- 折叠
摘要
Abstract
Objective:To investigate the curative effect and prognosis of intensity-modulated radiation therapy(IMRT)combined with transarterial chemoembolization(TACE)in treating advanced hepatocellular carcinoma(HCC).Methods:A retrospective analysis was conducted on 114 patients with advanced HCC who admitted to Anhui provincial cancer hospital from December 2015 to December 2021.All patients received IMRT combined with TACE.Univariate and multivariate COX survival analysis were performed to determine the independently predictive factors that affected survival period of patients.Results:The total effective rate(complete remission + partial remission)after IMRT combined with TACE was 60.5%(69/114)for all patients.Multivariate analysis revealed that larger tumor diameter,high score of Eastern Cooperative Oncology Group(ECOG),Ⅲ-Ⅳ portal vein tumor thrombosis(PVTT),hepatitis treatment status and elevated white blood cell count were independently predictive factors of affecting survival period of patients.Conclusion:The Ⅲ/Ⅳ PVTT of tumor and larger tumor diameter have significant influences on survival of patients,and other important factors that affect the survival of patients include physical condition of patients,hepatitis treatment and systemic inflammation.IMRT combined with TACE has better curative effect for advanced HCC,but the influence factors of prognostic survival should be fully considered.关键词
肝细胞癌(HCC)/癌栓/经动脉化疗栓塞(TACE)/三维适形调强放射治疗(3D-IMRT)Key words
Hepatocellular carcinoma/Tumor thrombosis/Transarterial chemoembolization(TACE)/Three dimensional intensity-modulated radiation therapy(3D-IMRT)分类
医药卫生引用本文复制引用
王鸿飞,杨柳,周解平,吴爱东..适形调强放射治疗联合经动脉化疗栓塞治疗晚期肝细胞癌的预后研究[J].中国医学装备,2024,21(4):13-17,5.
