中国医学装备2024，Vol.21Issue(4)：84-89,6.DOI:10.3969/j.issn.1672-8270.2024.04.017
多普勒超声血流参数及血清脑钠肽、胰岛素生长因子-1水平与子痫前期病情及预后的相关性分析
Correlation analysis of Doppler ultrasound blood flow parameters,serum BNP and IGF-1 with the disease condition and prognosis of patients with preeclampsia
摘要
Abstract
Objective:To explore the correlation between Doppler ultrasound blood flow parameters,serum brain natriuretic peptide(BNP)and insulin growth factor-1(IGF-1)with the disease condition and prognosis of preeclampsia(PE).Methods:A retrospective analysis was conducted on 162 pregnant women at Wanning People's Hospital from February 2019 to May 2021.Among them,80 normal pregnant women were included in the healthy control group,and 82 PE pregnant women were included in the observation group.All of them underwent serum BNP,IGF-1 and ultrasound examination.Based on the receiver operating characteristic(ROC)curve,the diagnostic efficacies of blood flow resistance index(RI),vascular index(VI),renal blood flow index(FI),IGF-1 and BNP were analyzed.The correlation between blood flow parameters,serum indicators and prognosis were analyzed through correlation analysis.Results:The BNP of the observation group was(90.61±41.71)pg/mL,which were higher than those of the healthy control group(t=12.334,P<0.05).The VI,FI and IGF-1 of observation group were respectively(17.35±4.86)%,(34.29±5.55)and(110.35±33.36)g/L,which were respectively lower than those of the healthy control group,and the differences were statistically significant(t=7.483,10.163,15.147,P<0.05).In the observation group,there were 48 cases of mild PE and 34 cases of severe PE.The BNP of patients with severe PE was(121.46±37.75)pg/mL,which was higher than that of patients with mild PE.The VI,FI and IGF-1 of patients with severe PE were respectively(13.94±0.24)%,(30.47±3.23)and(89.86±24.17)g/L,which were respectively lower than those of patients with mild PE.According to Spearman's analysis,both the severity and prognosis of the disease were negatively correlated with VI,FI,and IGF-1,and were positively correlated with BNP.ROC curve analysis showed that the area under curve(AUC)values of RI,VI,FI,IGF-1,BNP and the combined diagnoses of the 5 indicators were respectively 0.500,0.888,0.873,0.772,0.862 and 0.983 in diagnosing severe PE.In the observation group,there were 67 cases with favorable prognosis and 15 cases with poor prognosis.The BNP of patients with poor prognosis was(87.56±16.35)pg/mL,which was significantly higher than that of patients with favorable prognosis(t=15.804,P<0.05),and VI,FI and IGF-1 of patients with poor prognosis were respectively(18.60±4.70)%,(33.40±3.56)and(112.35±35.22)g/L,which were respectively lower than those of patients with favorable prognosis,and the differences were statistically significant(t=2.574,5.362,8.750,P<0.05).Conclusion:Serum BNP,IGF-1 level and Doppler ultrasound blood flow parameters have a certain correlation with PE condition and prognosis,which can provide objective basis for subsequent treatment and prognosis.关键词
多普勒超声/血流参数/脑钠肽(BNP)/胰岛素生长因子-1(IGF-1)/子痫前期/预后Key words
Doppler ultrasound/Blood flow parameter/Brain natriuretic peptide(BNP)/Insulin like growth factor-1(IGF-1)/Preeclampsia(PE)/Prognosis分类
医药卫生引用本文复制引用
李辉丽,李秋枫,冯业平,石莉,李香玉..多普勒超声血流参数及血清脑钠肽、胰岛素生长因子-1水平与子痫前期病情及预后的相关性分析[J].中国医学装备,2024,21(4):84-89,6.基金项目
海南省卫生健康委员会科研项目(21A200248) Research project of Hainan Provincial Health Commission(21A200248) （21A200248）
