我国老年人莫西沙星用药错误报告分析及防范建议OACSTPCD

Objective To analyze the characteristics of moxifloxacin-related medication errors(MEs)among the elderly in China,and to propose preventive suggestions.Methods The moxifloxacin-related ME reports of the Chinese elderly(≥60 years)from September 22,2012 to September 22,2022 were extracted from the National Monitoring Network for Clinical Safe Medication,the grade and content of MEs,the personnel who made MEs,the place where the MEs occurred,the discoverers and the factors inducing MEs were analyzed.Results There were 177 moxifloxacin-related ME reports,from 15 provincial administrative regions and 64 hospitals nationwide,involving 177 patients,including 109 males(61.58%)and 68 females(38.42%),aged in the range of 60 to 97 years,with a median age of 73 years.There were 124 cases of B-grade MEs(70.06%),33 cases of C-grade MEs(18.64%),10 cases of D-grade MEs(5.65%),seven cases of E-grade MEs(3.95%),and three cases of F-grade MEs(1.69%).Among the above MEs,there were 10 cases of serious MEs(grade E and above),including five cases of liver function-related MEs,one case of skin redness induced by rapid infusion rate,one case of infusion reaction induced by incorrect identity recognition,one case of prolonged QT interval induced by combined use of amiodarone,one case of dizziness and dry mouth induced by reuse of moxifloxacin in the presence of a history of allergy,and one case of prolonged hospital stay due to not adjusting the treatment regimen based on the drug sensitivity test.The main personnel who made MEs were physicians(177 cases,66.10%).The main place where the MEs occurred was the ward(81 cases,45.76%).The main discoverers were pharmacists(129 cases,72.88%).The most common ME content was the variety of drugs(54 case times,27.55%).The main factor inducing MEs was the personnel(126 case times,68.48%).Conclusion For the Chinese elderly patients(≥60 years),we should pay attention to MEs in the prescribing and dispensing processes when using moxifloxacin in clinical practice.