中国肿瘤生物治疗杂志2024，Vol.31Issue(4)：319-325,7.DOI:10.3872/j.issn.1007-385x.2024.04.001
肿瘤相关中性粒细胞的异质性及潜在的临床意义
Heterogeneity and potential clinical significance of tumor-associated neutrophils
摘要
Abstract
In malignant tumor tissues,tumor-associated neutrophils(TANs)have become a crucial component of the tumor microenvironment.The role of TANs in tumors is multifaceted.On one hand,TANs can directly kill tumor cells or mediate the collaborative anti-tumor activities of other immune cells.On the other hand,TANs can promote tumor angiogenesis,extracellular matrix remodeling,and tumor cell immune evasion.The heterogeneity of these functions of TAN is formed under regulation by various mechanisms within the tumor microenvironment and plays an important role in tumor development or suppression,thus making it crucial to investigate the mechanisms underlying TAN heterogeneity and functional transitions in tumors and their potential clinical significance.These investigations not only help develop suppressive drugs and therapies targeting pro-tumor neutrophil subpopulations,but also further promote the establishment and screening of new evaluation standards for more immunotherapy beneficiary population groups.关键词
肿瘤/肿瘤相关中性粒细胞/中性粒细胞异质性/免疫治疗/免疫抑制Key words
tumor/tumor-associated neutrophil(TAN)/neutrophil heterogeneity/immunotherapy/immunosuppression分类
医药卫生引用本文复制引用
张铎,路丽明..肿瘤相关中性粒细胞的异质性及潜在的临床意义[J].中国肿瘤生物治疗杂志,2024,31(4):319-325,7.基金项目
国家自然科学基金青年项目(No.82103316) （No.82103316）
国家自然科学基金项目(No.82071856,No.81671579,No.31370904) （No.82071856,No.81671579,No.31370904）
国家重点研发计划(No.2020YFA0113101) （No.2020YFA0113101）
上海市科委"科技创新行动计划"港澳台科技合作项目(No.22490760400) （No.22490760400）
上海市卫健委中医药科研项目(No.2020JP009) （No.2020JP009）
上海市教育委员会曙光计划项目(No.16SG14) （No.16SG14）
