中华骨质疏松和骨矿盐疾病杂志2024，Vol.17Issue(1)：62-66,5.DOI:10.3969/j.issn.1674-2591.2024.01.008
NLRP3炎性小体参与骨质疏松症关键细胞调节机制的研究进展
Role of NLRP3 inflammasome in key cellular regulatory mechanisms in osteoporosis
摘要
Abstract
Recent studies have shown that chronic inflammation and aging drive can cause osteopenia,leading to the occurrence of osteoporosis.The occurrence and development of chronic inflammation is closely related to the activation of inflammasomes,among which the activation of nucleotide-binding oligomerization domain-like receptor family pyrin do-main 3(NLRP3)inflammasome has attracted the attention.In this article,the literature was reviewed and the structure and regulatory mechanism of NLRP3 inflammasome,the effects of NLRP3 inflammasome on osteoclasts,osteoblasts and bone marrow mesenchymal stem cells,and the role of NLRP3 inflammasome in the development of osteoporosis were sum-marized,so as to provide new ideas for the study of the inflammatory mechanism of osteoporosis.关键词
NLRP3/骨质疏松症/炎性小体/成骨细胞/破骨细胞Key words
NLRP3/osteoporosis/inflammasome/osteoblast/osteoclast分类
医药卫生引用本文复制引用
李嘉仪,林吉生,费琦..NLRP3炎性小体参与骨质疏松症关键细胞调节机制的研究进展[J].中华骨质疏松和骨矿盐疾病杂志,2024,17(1):62-66,5.基金项目
北京市自然科学基金(7222033) （7222033）
