NLRP3炎性小体参与骨质疏松症关键细胞调节机制的研究进展OA北大核心CSTPCD

Recent studies have shown that chronic inflammation and aging drive can cause osteopenia,leading to the occurrence of osteoporosis.The occurrence and development of chronic inflammation is closely related to the activation of inflammasomes,among which the activation of nucleotide-binding oligomerization domain-like receptor family pyrin do-main 3(NLRP3)inflammasome has attracted the attention.In this article,the literature was reviewed and the structure and regulatory mechanism of NLRP3 inflammasome,the effects of NLRP3 inflammasome on osteoclasts,osteoblasts and bone marrow mesenchymal stem cells,and the role of NLRP3 inflammasome in the development of osteoporosis were sum-marized,so as to provide new ideas for the study of the inflammatory mechanism of osteoporosis.