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胃癌靶向及免疫治疗进展OACSTPCD

Progress of Targeted Therapy and Immunotherapy for Gastric Cancer

中文摘要英文摘要

胃癌是中国常见的消化道恶性肿瘤,具有发病率和死亡率高、进展期患者占比高的特点.既往胃癌的治疗以化疗为主,HER2阳性胃癌可应用曲妥珠单抗.由于胃癌的高度异质性,以致胃癌的药物研发及临床研究进展不尽人意.近几年,随着免疫治疗的进展及新靶点在胃癌中的探索,胃癌治疗取得了重大突破.本文就胃癌靶向和免疫治疗研究进展作简要综述.

Gastric cancer(GC)is a common malignant tumor of the digestive tract in China.It is characterized by high morbidity,mortality,and proportion of patients in advanced stages.In the past years,chemotherapy was used as the main treatment for GC.Subsequently,targeted therapy with trastuzumab was approved to treat HER2-positive GC.However,the progress of drug development and clinical studies has been limited by the high heterogeneity of GC.In recent years,research on immunotherapy and new targets for therapeutic exploration in GC has made great strides.Herein,we provide a brief review of the progress of the research on targeted therapy and immunotherapy for GC.

郑宇;潘宏铭

310063 杭州,浙江大学医学院附属邵逸夫医院肿瘤内科

临床医学

胃癌靶向治疗免疫治疗

Gastric cancerTargeted therapyImmunotherapy

《肿瘤防治研究》 2024 (004)

234-239 / 6

10.3971/j.issn.1000-8578.2024.23.1257

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