肿瘤防治研究2024，Vol.51Issue(4)：284-289,6.DOI:10.3971/j.issn.1000-8578.2024.23.1062
snoRNAs在肝癌中潜在作用的研究进展
snoRNAs and Its Potential Role in Hepatocellular Carcinoma
摘要
Abstract
Small nucleolar RNAs(snoRNAs)are non-coding RNAs in the nucleolus and are mainly responsible for the 2'-O-methylation and pseudouridine modification of rRNA.snoRNAs regulate various biological processes,such as tRNA modification,spliceosome snRNA modification,maintenance of the telomere structure,and alternative splicing of mRNA.Aberrant expression of snoRNA is related to cancer progression,and it may become a new target for cancer treatment.snoRNAs are stable and easy to detect in body fluids,so they can be used as a biomarker for clinical diagnosis and prognostic.This article reviews the biogenesis,classification,structure,and function of snoRNAs and introduces their potential role in the occurrence and development of hepatocellular carcinoma.关键词
核仁小RNA/肝癌/作用机制Key words
Small nucleolar RNAs/Hepatocellular carcinoma/Mechanism of action分类
医药卫生引用本文复制引用
宋馨馨,汪旭,倪娟..snoRNAs在肝癌中潜在作用的研究进展[J].肿瘤防治研究,2024,51(4):284-289,6.基金项目
National Natural Science Foundation of China(No.31860301). 国家自然科学基金(31860301) （No.31860301）
