肿瘤综合治疗电子杂志2024，Vol.10Issue(2)：131-139,9.DOI:10.12151/JMCM.2024.02-14
头颈癌放疗患者中性粒细胞与淋巴细胞比值的变化轨迹与重度放射性口腔黏膜炎的风险研究
Risk research on neutrophil to lymphocyte ratio trajectories and severe radiotherapy-induced oral mucositis in head and neck cancer patients undergoing radiotherapy
摘要
Abstract
Objective To identify the neutrophil to lymphocyte ratio(NLR)trajectories in head and neck cancer(HNC)patients during radiotherapy and to analyze the relationship between NLR trajectories and severe radiotherapy-induced oral mucositis(RIOM).Method A retrospective longitudinal study design was used.180 cases of HNC patients who received radiotherapy in Xiangya Hospital of Central South University from July 2022 to August 2023 were enrolled for the research.Neutrophil counts and lymphocyte counts were collected at baseline before radiotherapy(T0)and 1 week after beginning radiotherapy(T1),2 weeks after beginning radiotherapy(T2),3 weeks after beginning radiotherapy(T3),4 weeks after beginning radiotherapy(T4),5 weeks after beginning radiotherapy(T5),6 weeks after beginning radiotherapy(T6),respectively.NLR was calculated at the seven time points.The optimal NLR trajectory subgroups were identified using the latent class growth model and growth mixed model.Logistic regression analysis was used to determine the relationship between the NLR trajectory subgroups and severe RIOM.Result There were two potential subgroups of NLR trajectories which were baseline low-level with rapid growth group(Class-1 group)and baseline high-level with rapid growth group(Class-2 group).The logistic regression analysis showed that the risk of severe RIOM in the Class-2 group was 3.67 times higher than that in the Class-1 group.After controlling for the interference of confounding factors,NLR trajectory subgroups was still a risk factor for severe RIOM,and the risk of severe RIOM was increased from 3.67 times to 27.0 times.Conclusion NLR can be used as a biomarker to predict severe RIOM.The population with higher NLR value has a higher risk of severe RIOM.关键词
头颈癌/中性粒细胞与淋巴细胞比值/重度放射性口腔黏膜炎/变化轨迹/潜类增长模型/增长混合模型Key words
Head and neck cancer/Neutrophil to lymphocyte ratio/Severe radiotherapy-induced oral mucositis/Change trajectory/Latent class growth model/Growth mixed model引用本文复制引用
刘美子,安然,曾巧苗,吴子童,高菲,陈文凤..头颈癌放疗患者中性粒细胞与淋巴细胞比值的变化轨迹与重度放射性口腔黏膜炎的风险研究[J].肿瘤综合治疗电子杂志,2024,10(2):131-139,9.基金项目
湖南省卫生健康委2023年度科研计划课题(D202309038051) （D202309038051）
