肿瘤综合治疗电子杂志2024，Vol.10Issue(2)：140-145,6.DOI:10.12151/JMCM.2024.02-15
微创McKeown食管癌根治术后疲劳综合征的相关危险因素分析
Analysis of risk factors related to postoperative fatigue syndrome after radical resection of minimally invasive McKeown esophageal cancer
摘要
Abstract
Objective To investigate the risk factors associated with postoperative fatigue syndrome(POFS)after radical resection of minimally invasive McKeown esophageal cancer.Method The clinical data of 80 patients with esophageal cancer who underwent minimally invasive McKeown surgery in Nantong Tumor Hospital from January 2022 to June 2023 were retrospectively collected,and the postoperative fatigue status of the included patients was evaluated according to the identity-consequence fatigue scale(ICFS),and the patients were divided into POFS group(n= 34)and non-POFS group(n= 46).The perioperative clinical data of the two groups were collected through electronic medical records and univariate analysis was performed,and finally multivariate Logistic regression was used to analyze the related factors of POFS.Result The total score of postoperative ICFS in 80 patients was(82.21±6.64)scores,which was significant higher than the preoperative score of(57.34±4.11)scores(P＜0.05),and their five dimensional scores(daily activity,energy,vitality,attention,and fatigue)were also significant higher than preoperative scores(all P＜0.05).The results of univariate analysis showed that 34 out of 80 patients experienced postoperative POFS,with an incidence rate of 42.50%.Univariate analysis showed that the age of POFS group was significantly older than that of non-POFS group(P＜0.05).The proportions of preoperative anxiety or depression,sleep disorders and hypoproteinemia in POFS group were significantly higher than those in non-POFS group(all P＜0.05),the proportion of preoperative 6-minute walking test(6MWT)distance＜350 m than group was significantly higher than that in non-POFS group(P＜0.05).The anesthesia time in POFS group was significantly shorter than that in non-POFS group(P＜0.05),the postoperative pain visual analogue scale(VAS)score,postoperative serum C-reactive protein(CRP)level and postoperative lactic acid level were significantly higher than those in non-POFS group(all P＜0.05),the postoperative hemoglobin(Hb)level was significantly lower than that in non-POFS group(P＜0.05).Multivariate Logistic regression analysis showed that preoperative anxiety or depression,hypoalbuminemia,preoperative 6MWT distance＜350 m,short anesthesia time,and high serum CRP level after surgery were independent risk factors for the occurrence of POFS in minimally invasive McKeown esophageal cancer radical surgery(all P＜0.05).Conclusion The incidence of POFS after minimally invasive McKeown esophageal cancer radical surgery is relatively high,and it is closely related to various factors such as preoperative anxiety and depression,hypoalbuminemia,short 6MWT distance,short anesthesia time,and high CRP level.Clinical practice should pay attention to these risk factors and develop targeted interventions to reduce the incidence of POFS.关键词
食管癌/微创手术/McKeown食管癌根治术/术后疲劳综合征/危险因素Key words
Esophageal cancer/Minimally invasive surgery/McKeown radical esophageal cancer resection/Postoperative fatigue syndrome/Risk factors引用本文复制引用
王鸿伟,胡敏,刘雷..微创McKeown食管癌根治术后疲劳综合征的相关危险因素分析[J].肿瘤综合治疗电子杂志,2024,10(2):140-145,6.基金项目
江苏省科技项目(BK20160132) （BK20160132）
