中国现代医生2024，Vol.62Issue(10)：1-5,5.DOI:10.3969/j.issn.1673-9701.2024.10.001
MEX3A、CDX2、MUC2与MUC5AC判断可癌变胃肠化生的应用价值
Application value of MEX3A,CDX2,MUC2 and MUC5AC in judging cancerous gastric mucosal intestinal metaplasia
摘要
Abstract
Objective To investigate the correlation between MEX3A and differentiation characteristics of gastric cancer and intestinal metaplasia,and its combination with caudal-related homeobox transcription factor 2(CDX2)and mucin 2(MUC2)and mucin 5AC(MUC5AC)to determine the role of carcinogenic intestinal metaplasia.Methods From January 2010 to December 2014,a total of 410 cases of gastric cancer and paracarcinoma paraffin-embedded tissue samples were selected from the Central Hospital Affiliated to Shenyang Medical College and the Second Hospital Affiliated to Shenyang Medical College.According to pathological diagnosis,they were divided into control group(mild superficial gastritis,79 cases),intestinal metaplasia group(149 cases)and gastric cancer group(182 cases).The expressions of MEX3A,CDX2,MUC2 and MUC5AC were detected by immunohistochemistry.Results MEX3A was highly expressed in gastric cancer group and intestinal metaplasia group,especially diffuse gastric cancer,poorly differentiated gastric cancer and type Ⅲ intestinal metaplasia(P<0.05).CDX2 and MUC2 were highly expressed in gastric cancer group and intestinal metaplasia group,especially intestinal type gastric cancer,highly and moderately differentiated gastric cancer,type Ⅰ and type Ⅱ intestinal metaplasia(P<0.05).The expression of MUC5AC was high in control group and low in gastric cancer group and intestinal metaplasia group,especially in intestinal type gastric cancer,type Ⅰ and type Ⅲ intestinal metaplasia(P<0.05).Gastric cancer and intestinal metaplasia differentiation were negatively correlated with MEX3A and MUC5AC expression,but positively correlated with CDX2 and MUC2 expression(P<0.05).MEX3A was negatively correlated with the expression of CDX2 and MUC2,and positively correlated with the expression of MUC5AC in gastric cancer(P<0.05).MEX3A was negatively correlated with the expression of CDX2 and MUC2 in intestinal metaplasia(P<0.05),while CDX2 was positively correlated with the expression of MUC2(P<0.05).Conclusion MEX3A is negatively correlated with gastric cancer and intestinal metaplasia differentiation.Gastric cancer is characterized by high MEX3A expression and low CDX2 and MUC2 expression.关键词
肠化生/胃癌/MEX3A/尾型同源盒转录因子2/黏蛋白2/黏蛋白5ACKey words
Intestinal metaplasia/Gastric cancer/MEX3A/Caudal-related homeobox transcription factor 2/Mucin 2/Mucin 5AC分类
医药卫生引用本文复制引用
张梦媛,王旭光,刘佳蕊,张忠,焦兰岚,张珉,薄威,勾佳钰,吴诚诚,杨旭东..MEX3A、CDX2、MUC2与MUC5AC判断可癌变胃肠化生的应用价值[J].中国现代医生,2024,62(10):1-5,5.基金项目
辽宁省自然科学基金项目(2022-NLTS-14-04 （）
2019-ZD-0319) （）
沈阳医学院硕士研究生科技创新基金(Y20220501) （Y20220501）
