中国现代医生2024，Vol.62Issue(10)：17-21,27,6.DOI:10.3969/j.issn.1673-9701.2024.10.005
杭州地区儿童变应性鼻炎的血清变应原检测分析
Detection of serum allergens in children with allergic rhinitis in Hangzhou
摘要
Abstract
Objective To analyze the distribution of common allergens in children with allergic rhinitis(AR)in Hangzhou,and to provide reference for its prevention and treatment.Methods From January 2020 to December 2022,13 521 children who were diagnosed with AR and underwent in vitro serum specific immunoglobulin E(sIgE)detection in Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University were selected as the research objects.The positive rates of allergens in children with AR of different genders,ages and seasons were compared.Results Among 13 521 children,the positive rate of sIgE was 54.49%(7367/13 521),of which 64.82%were allergic to only one allergen.Among the 19 common allergens,the top three overall positive rates were household dust mite(44.27%),milk(14.62%),and mixed grass(4.82%).The positive rates of allergens of house dust mites,cat hair dander,mulberry,mold combination,tree pollen combination,amaranth,cockroach,milk,shrimp,crab,pineapple,shellfish and mango in male children were significantly higher than those in female children(P<0.05).The positive rates of allergens of house dust mite,mixed grass,cat hair dander,mulberry,mold combination,egg white,shrimp,crab,pineapple,cashew nuts and shellfish in different age groups were statistically significant(P<0.05).July and August were the two months with the highest allergen positive rate.The allergen positive rates of house dust mite,dog and cat hair dander were the highest in summer,and the allergen positive rate of plants was consistent with the flowering season.The sIgE concentration of house dust mite(77.87%)was mainly grade 3 and above.The sIgE concentration of other allergens was mainly grade 1 and 2.Conclusion Dust mites and milk are the most common allergens in children with AR in Hangzhou,and the distribution of allergens varies with gender,age and season.Allergen detection can provide a more accurate plan for the diagnosis,prevention and treatment of AR.关键词
儿童/变应性鼻炎/变应原/特异性免疫球蛋白EKey words
Children/Allergic rhinitis/Allergen/Specific immunoglobulin E分类
医药卫生引用本文复制引用
谢琳,马志祺,朱晓灿,刘可欣,李勇..杭州地区儿童变应性鼻炎的血清变应原检测分析[J].中国现代医生,2024,62(10):17-21,27,6.基金项目
浙江省中医药科技计划项目(2023ZL569) （2023ZL569）
杭州市医药卫生科技项目(A20210107) （A20210107）
