中国现代医生2024，Vol.62Issue(10)：32-35,4.DOI:10.3969/j.issn.1673-9701.2024.10.008
肝素结合蛋白对脓毒症患者血管通透性影响的研究
Effect of heparin-binding protein on vascular permeability in patients with sepsis
摘要
Abstract
Objective To investigate the correlation between heparin-binding protein(HBP)and vascular permeability in patients with sepsis.Methods Four hundred infected patients admitted to Affiliated Jinhua Hospital Zhejiang University School of Medicine from November 2019 to November 2022 were retrospectively selected and divided into sepsis group(n=190)and non-sepsis group(n=210)according to whether they were diagnosed with sepsis or not.HBP,the difference between hematocrit(HCT)and serum albumin(ALB)(HCT-ALB)and percentage of fluid overload were compared between two groups.Pearson method was used to analyze the correlation between HBP,HCT-ALB and percentage of liquid overload.Results HBP,HCT-ALB and percentages of fluid overload in sepsis group were significantly higher than those in non-sepsis group(P<0.05).Pearson correlation analysis showed that serum HBP level was positively correlated with HCT-ALB and percentage of fluid overload 24h after admission(P<0.05).Conclusion Increased vascular permeability in patients with sepsis may be related to the high level of HBP released by neutrophils stimulated by bacterial toxins.关键词
脓毒症/肝素结合蛋白/血管通透性/液体超负荷Key words
Sepsis/Heparin-binding protein/Vascular permeability/Fluid overload分类
医药卫生引用本文复制引用
朱秀琪..肝素结合蛋白对脓毒症患者血管通透性影响的研究[J].中国现代医生,2024,62(10):32-35,4.基金项目
浙江省金华市科技计划项目(2021-4-037) （2021-4-037）
