中国现代医生2024，Vol.62Issue(10)：52-55,4.DOI:10.3969/j.issn.1673-9701.2024.10.013
加味健肾方治疗特发性膜性肾病脾肾两虚证患者的疗效及对PLA2R的影响
Effect of Jiawei Jianshen prescription on patients with spleen-kidney deficiency of idiopathic membranous nephropathy and its influence on PLA2R
摘要
Abstract
Objective To observe the effect of Jiawei Jianshen prescription on idiopathic membranous nephropathy(IMN)with spleen-kidney deficiency and its influence on phospholipase A2 receptor(PLA2R)titer.Methods A total of 60 patients with IMN who were hospitalized or outpatients in Liuzhou Traditional Chinese Medical Hospital from January 2021 to July 2022 were selected and divided into control group and treatment group by simple random sampling method,with 30 cases in each group.The control group was given basic treatment alone,and the treatment group was given Jiawei Jianshen prescription + basic treatment.Blood urea nitrogen(BUN),serum creatinine(SCr),serum albumin(ALB),24h urinary protein quantitative and PLA2R titer were compared between two groups before and after treatment.The therapeutic effect of two groups was evaluated.Results The total effective rate of treatment group was significantly higher than that of control group(χ2=60.000,P<0.001).After treatment,the scores of edema,abdominal distension,fatigue,soreness and weakness of waist and knees in treatment group were significantly lower than those in control group(P<0.05).24h urinary protein and PLA2R titer in treatment group were significantly lower than those in control group,and ALB was significantly higher than that in control group(P<0.05).Conclusion Jiawei Jianshen prescription can significantly improve the clinical symptoms of IMN patients with spleen-kidney deficiency,increase serum ALB level,reduce 24h urinary protein quantity and PLA2R titer.关键词
特发性膜性肾病/脾肾两虚证/磷脂酶A2受体Key words
Idiopathic membranous nephropathy/Spleen-kidney deficiency pattern/Phospholipase A2 receptor分类
医药卫生引用本文复制引用
刘朝业,黄荣贵,张威英,谢议凤,陈柱..加味健肾方治疗特发性膜性肾病脾肾两虚证患者的疗效及对PLA2R的影响[J].中国现代医生,2024,62(10):52-55,4.基金项目
广西中医药管理局自筹经费科研课题项目(GZZC2020402) （GZZC2020402）
广西中医药大学自然科学研究项目(面上项目)(2020MS054) （面上项目）
