中国现代医生2024，Vol.62Issue(10)：56-59,4.DOI:10.3969/j.issn.1673-9701.2024.10.014
俞氏清热活血方对溃疡性结肠炎模型大鼠结肠黏膜的影响
The effect of Yu's Qingre Huoxue prescription on colonic mucosa of ulcerative colitis model rats
摘要
Abstract
Objective To investigate the effect of Yu's Qingre Huoxue prescription enema on colonic mucosa in rats with ulcerative colitis(UC).Methods A total of 30 Wistar rats were randomly divided into blank control group,model group,mesalazine group,Chinese medicine high-dose,medium-dose and low-dose groups(5 rats in each group).After successful modeling with trinitrobenzene sulfonic acid,the rats were given 14 days enema with distilled water,mesalazine suspension,and high,medium and low concentration Yu's Qingre Huoxue prescription.The general condition and weight changes of rats were recorded daily,and colon macroscopic damage index(CMDI)and mucosal injury score under microscope of rats in each group were compared.Results Compared with blank control group,the weight of rats in model group decreased significantly(P<0.05).The blank control group had normal water and food intake and activity,glossy fur and normal stool.The rats in model group and each administration group were found to have anal fouling,residual blood in stool,decreased appetite,messy fur,dim luster and other conditions,and the above conditions were gradually improved after enema treatment.Compared with blank control group,the CMDI and mucosal injury scores of model group were significantly increased(P<0.05).Compared with model group,CMDI and mucosal injury scores of mesalazine group and Chinese medicine high-dose,medium-dose and low-dose groups were significantly decreased(P<0.05).Conclusion Yu's Qingre Huoxue prescription can effectively improve the clinical symptoms of diarrhea,mucous,pus and blood stools in UC model rats,reduce the damage of colonic mucosa,promote mucosal repair,and have a good effect on the treatment of UC in rats.关键词
俞氏清热活血方/溃疡性结肠炎/结肠黏膜损伤指数/结肠黏膜损伤评分Key words
Yu's Qingre Huoxue prescription/Ulcerative colitis/Colon macroscopic damage index/Colonic mucosal injury score分类
医药卫生引用本文复制引用
杨一天,陈雯婧,叶蔚..俞氏清热活血方对溃疡性结肠炎模型大鼠结肠黏膜的影响[J].中国现代医生,2024,62(10):56-59,4.基金项目
浙江省杭州市医药卫生科技计划项目(0020190373) （0020190373）
