遵义医科大学学报2024，Vol.47Issue(4)：392-400,9.
静息态功能MRI对儿童及青少年难治性颞叶癫痫脑动态功能连接研究
A resting-state functional MRI study of brain dynamic functional connectivity in children and adolescents with drug-resistant temporal lobe epilepsy
摘要
Abstract
Objective To investigate the relationship between dynamic functional connectivity(dFC)and cogni-tive changes in children and adolescents with drug-resistant temporal lobe epilepsy(DRTLE)where conventional MRI results are negative.Methods A total of 41 DRTLE patients and 35 healthy controls underwent assessment using the Wechsler Intelligence Scale for Children and imaging with T2-fluid attenuated inversion recovery,threee-dimension T1 weighted imaging,and resting state functional magnetic resonance imaging.Through independent component analysis and sliding time window methods,two-sample t-tests were used to compare the differences in dFC and temporal properties between the two groups.Additionally,correlation analyses were conducted between altered temporal properties and the age at onset,duration,seizure frequency,and intelligence scores.Results Compared to the healthy control group,the patient group demonstrated statistically significant differences in dFC across four states(q＜0.05,FDR corrected).Between-group comparison:DRTLE patients exhibited weakened dFC in state 2 and increased connectivity in states 1,3,and 4;Furthermore,fraction time and mean dwell time differed between states 1-3,while the number of transitions did not differ between groups;The DRTLE group had lower intelligence scores compared to the healthy control group.Correlation analysis revealed a negative correla-tion between the fraction time in state 1 and the duration(r=-0.337,P=0.031),a positive correlation be-tween mean dwell time and the duration of the disease(r=0.401,P=0.009),and negative correlations be-tween mean dwell time in state 1 and verbal comprehension and perceptual reasoning(r=-0.323,P=0.039;r=-0.323,P=0.040).Conclusion The findings suggest that altered dynamic function connectivity in DRTLE is associated with the duration of the disease and cognitive function.Changes in dynamic brain network properties may serve as potential biomarkers for studying cognitive changes and neural mechanisms in DRTLE.关键词
难治性癫痫/功能磁共振/动态脑网络/独立成分分析/滑动时间窗Key words
drug-resistant epilepsy/functional magnetic resonance imaging/dynamic brain networks/inde-pendent component analysis/sliding time window分类
医药卫生引用本文复制引用
何玉伦,冉海峰,谢雨辛,李清会,胡杰,陈贵琴,张体江..静息态功能MRI对儿童及青少年难治性颞叶癫痫脑动态功能连接研究[J].遵义医科大学学报,2024,47(4):392-400,9.基金项目
国家自然科学基金面上项目(NO:82171919) （NO:82171919）
贵州省高等学校智能医学影像工程研究中心[NO:黔教技(2023)038]. （2023）
