遵义医科大学学报2024，Vol.47Issue(4)：416-423,8.
红景天苷改善创伤性脑损伤后继发性神经损伤的作用机制研究进展
Research progress on the mechanism of salidroside in improving secondary brain injury after trauma brain injury
摘要
Abstract
Traumatic brain injury(TBI)is a complex direct injury to the head caused by traffic accidents,falls,etc.,including primary brain injury and secondary brain injury.Secondary biochemical cascade reactions(such as oxidative stress,inflammation and glutamate neurotoxicity)generated by Secondary traumatic brain in-jury(sTBI)are the main causes of neurological dysfunction.Salidroside(Sal)is a natural phenolic product iso-lated from Rhodiola rosea Rhizome,which has neuroprotective effects such as anti-oxidation,inhibiting inflam-mation and apoptosis,blocking neurotransmission and so on.Because of its remarkable effect in neuroprotection and few side effects,it has become a research hotspot in the treatment of secondary brain injury after TBI.Al-though there have been extensive clinical studies on the treatment of sTBI,there is still no summary of the mech-anism by which Sal can improve the neurological dysfunction caused by sTBI.Therefore,this paper summarizes the latest research progress and mechanism of action of Sal in improving the secondary neurological dysfunction of TBI,in order to provide references for the clinical application of Sal to improve such diseases and their complica-tions.关键词
创伤性脑损伤/继发性脑损伤/红景天苷/氧化应激反应/炎症反应/谷氨酸兴奋性神经毒性反应Key words
traumatic brain injury/secondary traumatic brain injury/salidroside/oxidative stress reaction/inflammatory response/glutamate excitatory neurotoxic reaction分类
医药卫生引用本文复制引用
陈琳,葛红飞,喻安永..红景天苷改善创伤性脑损伤后继发性神经损伤的作用机制研究进展[J].遵义医科大学学报,2024,47(4):416-423,8.基金项目
国家自然科学基金资助项目(NO:82060245) （NO:82060245）
省部共建协同创新中心项目[NO:教科技厅函(2020)39]. （2020）
