动物医学进展2024，Vol.45Issue(5)：86-90,5.
宿主上皮细胞非编码RNA调控隐孢子虫感染的分子机制研究进展
Progress on Molecular Mechanisms of Cryptosporidium Infection Regulated by Noncoding RNA of Host Epithelial Cells
摘要
Abstract
Cryptosporidium are important zoonotic pathogens distributed worldwide,and their infections can lead to severe diarrhea or even death in humans and animals,which seriously threatens human health and animal husbandry development.At present,little is known about the mechanism of Cryptosporidium invasion,pathogenesis,and the regulatory mechanism of host defense against Cryptosporidium infection,which is one of the important bottlenecks hindering the development of therapeutic drugs and vaccines.According to studies,host epithelial cell non-coding RNAs(ncRNAs)are involved in regulating many biological processes against Cryptosporidium infection,such as regulating cytokine release,TLR/NF-κB and other signaling pathways,inflammatory response,and apoptosis.This review focuses on the mechanisms of host epithelial cell microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)in defense against Cryptosporidium infection.关键词
上皮细胞/隐孢子虫/miRNA/lncRNA/circRNA/作用机制Key words
epithelial cell/Cryptosporidium/miRNA/lncRNA/circRNA/mechanism of action分类
农业科技引用本文复制引用
邵天人,吴善博,张雅芳,谢静静,赵利杰,孙露露,边啸坤,王荣军..宿主上皮细胞非编码RNA调控隐孢子虫感染的分子机制研究进展[J].动物医学进展,2024,45(5):86-90,5.基金项目
国家自然科学基金项目(U2004155) （U2004155）
河南省杰出青年科学基金项目(222300420010) （222300420010）
