国际口腔医学杂志2024，Vol.51Issue(3)：362-367,6.DOI:10.7518/gjkq.2024043
口腔鳞状细胞癌嗜神经侵袭的研究进展
Research progress on perineural invasion of oral squamous cell carcinoma
摘要
Abstract
Oral squamous cell carcinoma(OSCC)is the most common malignant tumor in the head and neck.OSCC seriously hampers patients'life and health because of its invasion,metastasis,and recurrence characteristics.Perineural invasion(PNI)is a common but occult pathologic characteristic of OSCC that reduces the survival rate of patients.How-ever,the clinical understanding of this high-rick biological behavior ability and mechanism remains insufficient.Recent studies have found that perineural invasion is a reciprocal communication between the tumor and nerves,which involves a variety of cells and molecules,and may become the target of future therapeutic intervention.This article reviews the re-search progress on the molecular pathological mechanism,prognostic value,and treatment of PNI in OSCC.关键词
口腔鳞状细胞癌/嗜神经侵袭/预后/分子机制Key words
oral squamous cell carcinoma/perineural invasion/prognosis/molecular mechanism分类
医药卫生引用本文复制引用
李冰芷,刘云坤,王文轩,侯泽宇,唐金茹,李龙江..口腔鳞状细胞癌嗜神经侵袭的研究进展[J].国际口腔医学杂志,2024,51(3):362-367,6.基金项目
National Natural Science Foundation of China(82141130,82372735) 国家自然科学基金(82141130,82372735) （82141130,82372735）
