国际口腔医学杂志2024，Vol.51Issue(3)：374-380,7.DOI:10.7518/gjkq.2024046
同源盒基因调控先天缺牙的研究进展
Recent advances in regulation of congenitally absent teeth by homeobox genes
摘要
Abstract
The homeobox gene is an evolutionarily conserved transcription factor containing homologous domain,and its encoded transcription regulatory factor plays an important role in organogenesis.Several subfamilies of the homeobox gene family are involved in the development of the maxillofacial region in vertebrates,and their abnormal expression is closely related to the occurrence of congenitally missing teeth.With the development of molecular genetics,genetic engi-neering,and human genome project,the study of newly discovered homeobox genes,mutation types,and expression pat-terns is becoming the main research direction of congenitally missing teeth diseases.This study reviews the literature on the latest research progress of homeobox genes in recent years,the expression patterns and molecular mechanisms of ho-meobox genes related to congenitally missing teeth,and the application prospect of homologous box gene in the clinical diagnosis and treatment of congenital missing teeth.关键词
同源盒基因/先天缺牙/非综合征性先天缺牙/牙齿发育/基因突变/牙组织再生工程/配对盒基因9/肌节同源异型盒基因1Key words
homeobox gene/congenitally missing teeth/nonsyndromic tooth agenesis/tooth development/gene mutation/dental tissue regeneration engineering/paired box 9/muscle segment homeobox gene 1分类
医药卫生引用本文复制引用
张伟杰,刘向晖,杨玉娥..同源盒基因调控先天缺牙的研究进展[J].国际口腔医学杂志,2024,51(3):374-380,7.基金项目
Qingdao Key Health Discipline Development Fund(2022-2024) （2022-2024）
Qingdao Clinical Research Center for Oral Diseases Fund(2021-2024) 青岛市医疗卫生重点学科建设项目(2022-2024) （2021-2024）
青岛市口腔疾病临床医学研究中心项目(2021-2024) （2021-2024）
