广西医科大学学报2024，Vol.41Issue(4)：629-635,7.DOI:10.16190/j.cnki.45-1211/r.2024.04.021
GLP-1RA治疗儿童和青少年2型糖尿病及肥胖症的研究进展
Research progress on clinical application and safety of GLP-1RA in children and teenagers with type 2 diabetes and obesity
摘要
Abstract
In recent years,the incidence rate of type 2 diabetes(T2DM)and obesity in children and teenagers in China is increasing year by year.However,currently there are limited drugs approved domestically for the treat-ment of T2DM and obesity in children and teenagers,and the failure rate is high.In recent years,studies have shown that glucagon like peptide-1 receptor agonists(GLP-1RA)are effective and have good short-term safety in lowering blood sugar and weight loss in children and teenagers with T2DM and obese patients.However,chil-dren and teenagers in the growth and development stage have different reactions and tolerance levels to GLP-1RA compared to adults,and the incidence of gastrointestinal adverse reactions and hypoglycemia is significantly increased.Therefore,it is necessary to pay attention to the safety of their long-term use,and more systematic re-search and long-term follow-up evaluation should be further conducted.关键词
胰高血糖素样肽-1受体激动剂/儿童/青少年/2型糖尿病/肥胖Key words
glucagon like peptide-1 receptor agonist/children/teenagers/type 2 diabetes/obesity分类
医药卫生引用本文复制引用
叶芳杏,伍黎芳,黎涛..GLP-1RA治疗儿童和青少年2型糖尿病及肥胖症的研究进展[J].广西医科大学学报,2024,41(4):629-635,7.基金项目
梧州市科技计划项目(No.202202149) （No.202202149）
