国际医药卫生导报2024，Vol.30Issue(7)：1066-1070,5.DOI:10.3760/cma.j.issn.1007-1245.2024.07.003
辣椒素受体在腹泻型肠易激综合征发病中的作用
Role of capsaicin receptors in pathogenesis of diarrheal irritable bowel syndrome
摘要
Abstract
Diarrheal irritable bowel syndrome(IBS-D)is one of the common functional gastrointestinal disorders characterized by intermittent abdominal pain and diarrhea.IBS-D is a chronic functional disease with a long course and easy recurrence of symptoms,and seriously affects the patients'quality of life.At present,it is believed that its pathogenesis is closely related to factors such as visceral hypersensitivity,brain-gut axis imbalance,intestinal flora imbalance,etc.Current studies have shown that capsaicin receptors are involved and play an important role.In this article,the specific mechanism of capsaicin receptors involved in visceral hypersensitivity,brain-gut axis imbalance,and intestinal flora imbalance is reviewed,so as to provide references for exploring the pathogenesis and therapeutic targets of IBS-D.关键词
腹泻型肠易激综合征/辣椒素受体/内脏高敏感/脑-肠轴/肠道菌群/综述Key words
Diarrheal irritable bowel syndrome/Capsaicin receptors/Visceral hypersensitivity/Brain-gut axis/Intestinal flora/Review引用本文复制引用
崔筱,刘亮..辣椒素受体在腹泻型肠易激综合征发病中的作用[J].国际医药卫生导报,2024,30(7):1066-1070,5.基金项目
山东省医药卫生科技发展计划(202003030878) Program of Medical and Health Science and Technology Development in Shandong Province(202003030878) （202003030878）
