口腔疾病防治2024，Vol.32Issue(6)：436-443,8.DOI:10.12016/j.issn.2096-1456.2024.06.005
外周血炎症指标与口腔鳞状细胞癌患者术后复发转移相关性研究
Correlation of multiple inflammatory indices in peripheral blood with postoperative recurrence and metastasis in oral squamous cell carcinoma patients
摘要
Abstract
Objective To investigate the associations of multiple immunoinflammatory markers in peripheral blood before and after operation,such as the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),lympho-cyte-to-monocyte ratio(LMR),systemic immune-inflammation index(SII)and systemic inflammatory response index(SIRI),with postoperative recurrence and metastasis in oral squamous cell carcinoma(OSCC)patients,to provide a refer-ence for predicting the prognosis of OSCC patients.Methods This study was approved by the hospital ethics commit-tee,and informed consent was obtained from the patients.A total of 160 patients with primary OSCC who underwent rad-ical surgery were grouped according to preoperative lymph node metastasis,degree of differentiation,clinical T stage,and postoperative recurrence and metastasis.The last preoperative and 1-month postoperative routine blood test results of all the patients were collected to analyze the relationship between peripheral blood inflammatory indicators,including the NLR,PLR,LMR,SII,and SIRI,before and after surgery.The above clinicopathological indicators and postoperative recurrence and metastasis were evaluated in OSCC patients.Results Among the 160 patients,there was a significant difference in the preoperative SII between the preoperative lymph node metastasis group and the no metastasis group(P＜0.05);the preoperative NLR,LMR,SII and SIRI were significantly different among the different differentiation degree groups(P＜0.05);and the preoperative SIRI in the different clinical T stage groups were significantly different(P＜0.05).The preoperative NLR,SII and SIRI were significantly different between the postoperative recurrence and metas-tasis group and the no recurrence and metastasis group(P＜0.05).Postoperative peripheral blood inflammatory markers were not associated with postoperative metastasis and recurrence.Univariate Cox analysis revealed that among the pre-operative peripheral blood inflammatory indicators,the preoperative NLR,PLR,SII and SIRI were the factors influenc-ing recurrence and metastasis in OSCC patients.Multivariate Cox analysis revealed that the preoperative NLR was the only independent risk factor for recurrence and metastasis in OSCC patients among the preoperative peripheral blood in-flammatory indicators.Conclusion Among the peripheral blood inflammatory indicators,the preoperative NLR is an independent risk factor for postoperative recurrence and metastasis in OSCC patients and has certain predictive value.关键词
口腔鳞状细胞癌/中性粒细胞-淋巴细胞比值/血小板-淋巴细胞比值/全身免疫炎症指数/系统性炎症反应指数/临床T分期/术前淋巴结转移/预后/复发转移Key words
oral squamous cell carcinoma/neutrophil-to-lymphocyte ratio/platelet-to-lymphocyte ratio/sys-temic immune-inflammation index/systemic inflammation response index/clinical T stage/preoperative lymph node metastasis/prognosis/recurrence and metastasis分类
医药卫生引用本文复制引用
姑海尔尼沙·开合热曼,吾兰·金恩斯,姚志涛..外周血炎症指标与口腔鳞状细胞癌患者术后复发转移相关性研究[J].口腔疾病防治,2024,32(6):436-443,8.基金项目
新疆维吾尔自治区科学技术厅"天山创新团队计划"项目(2023D14007) This study was supported by the grants from Xinjiang Uygur Autonomous Region Science and Technology Department"Tianshan Innovation Team Program"Project(No.2023D14007). （2023D14007）
