口腔疾病防治2024，Vol.32Issue(6)：451-456,6.DOI:10.12016/j.issn.2096-1456.2024.06.007
抗菌光动力疗法辅助龈下刮治治疗慢性牙周炎临床效果观察
Clinical observation of antibacterial photodynamic therapy assisted subgingival curettage for the treatment of chronic periodontitis
摘要
Abstract
Objective To investigate the efficacy of antibacterial photodynamic therapy(aPDT)as an adjunct to subgingival scaling and root planning in the treatment of chronic periodontitis.Methods This study followed medical ethics guidelines,and informed consent was obtained from all patients.Sixteen patients were recruited for this random-ized split-mouth controlled trial.The control group underwent subgingival scaling and root planning(SRP),while the ex-perimental group received subgingival scaling and root planing plus aPDT treatment using Perowave® with a toluidine blue O solution photosensitizer.The probing pocket depth(PD),recession,plaque index(PLI),bleeding index(BI)and proportion of positive sites of bleeding on probing(BOP)(BOP%)at all sites were examined at baseline(before treat-ment)and at 1,3 and 6 months after treatment.Results Follow-up was completed for 13 patients.On the control side,356 teeth were tested at 2 136 sites.A total of 360 teeth on the test side and 2 160 sites were included in the study.Before treatment,there was no significant difference in the baseline indicators between the two groups.After treatment,both groups showed significant improvement in clinical parameters,including PD,PLI,BI,and BOP%,compared with baseline.At 3 months,the BOP%and PLI in the experimental group were significantly lower than those in the control group(P＜0.05).The improvement in BOP%and PLI in the experimental group was significantly greater than that in the control group 3 months after treatment(P＜0.05).Conclusion aPDT,as an adjuvant treatment to SRP for chronic periodontitis,can improve gingival bleeding and control periodontal inflammation in the early stage.关键词
慢性牙周炎/抗菌光动力疗法/牙周基础治疗/龈下刮治和根面平整/探诊深度/菌斑指数/出血指数/探诊出血Key words
chronic periodontitis/antibacterial photodynamic therapy/periodontal initial therapy/scaling and root planing/probing depth/plaque index/bleeding index/bleeding on probing分类
医药卫生引用本文复制引用
王新林,唐文珺,姜亦洋,石燕,晏子琪,王冬青..抗菌光动力疗法辅助龈下刮治治疗慢性牙周炎临床效果观察[J].口腔疾病防治,2024,32(6):451-456,6.基金项目
北京市科技新星计划项目(20230484447),北京市属医院科研培育项目(PX2019056) This study was supported by the grants from Beijing Science and Technology New Star Project(No.20230484447) （20230484447）
Bei-jing Municipal Administration of Hospitals Incubating Program(No.PX2019056). （No.PX2019056）
