口腔疾病防治2024，Vol.32Issue(6)：463-469,7.DOI:10.12016/j.issn.2096-1456.2024.06.009
组蛋白乙酰化/甲基化在口腔疾病中的研究进展
Research progress on histone acetylation/methylation in oral diseases
摘要
Abstract
Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities.Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.Histone acetylation and methylation increase or decrease in an orderly manner to regulate the development of teeth.Fluoride ions can destroy the balance between histone acetylation and methylation,which may be related to the occurrence of dental fluorosis.In addition,histone acetylation and methylation are involved in the regula-tion of oral inflammatory diseases.In the inflammatory microenvironment,the expression of histone acetyltransferase GCN5 decreases,and the expression of Dickkopf 1(DKK1)decreases,activating the Wnt/β-catenin pathway and ulti-mately inhibiting the osteogenic differentiation of periodontal ligament stem cells.Enhancer of zeste homolog 2(EZH2)and H3K27me3 levels were decreased in inflamed dental pulp tissues and cells.EZH2 inhibition inhibited the expres-sion of interleukin(IL)-1b,IL-6 and IL-8 in human dental pulp cells under inflammatory stimulation.Histone acetyla-tion/methylation modifications can interact with multiple signaling pathways to promote the occurrence and development of oral tumors and are related to the high invasiveness of salivary gland tumors.Small molecule drugs targeting histone acetylation and methylation-related enzymes can regulate the level of histone methylation/acetylation and have shown po-tential in the treatment of oral and maxillofacial diseases.For example,the histone deacetylase inhibitor vorinostat can inhibit the secretion of inflammation-related cytokines;it also promotes the maturation of odontoblasts and the formation of dentin-related matrix,demonstrating its potential in pulp preservation.Understanding the role of histone acetylation/methylation modifications in the occurrence and development of oral diseases will help promote research on epigenetic modifications in oral diseases and provide new perspectives for disease diagnosis and treatment.关键词
组蛋白修饰/组蛋白甲基化/组蛋白去甲基化/组蛋白乙酰化/组蛋白去乙酰化/组蛋白去甲基酶抑制剂/组蛋白去乙酰化酶抑制剂/氟牙症/牙周炎/牙髓炎Key words
histone modification/histone methylation/histone demethylation/histone acetylation/histone deacetylation/histone demethylase inhibitors/histone deacetylase inhibitors/dental fluorosis/periodontitis/pulpitis分类
医药卫生引用本文复制引用
罗煜川,李飞飞,余钒源,尹贝,叶玲..组蛋白乙酰化/甲基化在口腔疾病中的研究进展[J].口腔疾病防治,2024,32(6):463-469,7.基金项目
国家自然科学基金(81825005,82001019) This study was supported by grants from the National Natural Science Foundation of China(No.81825005 and No.82001019). （81825005,82001019）
