口腔疾病防治2024，Vol.32Issue(6)：470-477,8.DOI:10.12016/j.issn.2096-1456.2024.06.010
A型肉毒素治疗肌源性颞下颌关节紊乱病的研究进展
Research progress on the application of botulinum toxin type A in the treatment of myogenous temporoman-dibular disorders
摘要
Abstract
Myogenous temporomandibular disorder(M-TMD)is one of the main subtypes of temporomandibular dis-order(TMD)and typically manifests as masticatory myofascial pain;the incidence of TMD has been increasing annually in recent years.Botulinum toxin type A(BTX-A)is a potent neurotoxin produced by Clostridium botulinum.BTX-A in-hibits the release of acetylcholine from the presynaptic membrane,thereby blocking neuromuscular junction signaling.The noncosmetic application of BTX-A in the oral and maxillofacial regions is a prominent research topic.In recent years,an increasing number of studies have focused on the application of BTX-A in the treatment of M-TMD.The re-sults of a literature review revealed that an appropriate dose(10-50 U unilaterally)of BTX-A administered in a single in-jection into the masticatory muscles can effectively treat myalgia over a period of 3-6 months.Common adverse effects,such as masticatory weakness and facial paralysis,are transient and can be avoided by standardized injection tech-niques.However,there is a lack of standardized guidelines for injection techniques in clinical practice.关键词
A型肉毒素/肌源性颞下颌关节病/颞下颌关节紊乱病/咀嚼肌/肌痛/乙酰胆碱/副作用/临床应用Key words
botulinum toxin type A/myogenous temporomandibular disorders/temporomandibular disorders/masticatory muscles/myalgia/acetylcholine/adverse effects/clinical application分类
医药卫生引用本文复制引用
陈奕帆,汤良晨,陈敏儿,张萧,唐贶昀,李志勇..A型肉毒素治疗肌源性颞下颌关节紊乱病的研究进展[J].口腔疾病防治,2024,32(6):470-477,8.基金项目
国家自然科学基金项目(82201016) （82201016）
口腔疾病研究国家重点实验室开放课题(SKLOD2023OF05) This study was supported by the grants from National Natural Science Foundation of China(No.82201016) （SKLOD2023OF05）
State Key Laboratory of Oral Diseases(SKLOD)Open Fund(No.SKLOD2023OF05). （SKLOD）
