赣南医学院学报2024，Vol.44Issue(3)：219-224,6.DOI:10.3969/j.issn.1001-5779.2024.03.001
桥粒胶蛋白2及其在肿瘤疾病中的研究进展
Desmocollin 2 and its research progress tumor diseases
摘要
Abstract
Desmosomes(DSM)are large assemblies of macromolecules that mechanically link the cytoskeleton of intermediate filaments to cadherin-mediated cell adhesion sites,providing structural integrity for the maintenance of mechanically stressed tissues such as skin,myocardium and gastrointestinal mucosa.Desmocollins(DSCs)are members of the cadherin supergene family,which play an important role in cell-to-cell adhesion.Desmocollin-2(DSC2)is a member of the DSC family and has been found to be abnormally expressed in several types of cancers.It can affect tumor cell invasion and metastasis and participate in tumor progression.The differential expression and regulation of DSC2 in different human diseases provide potential targets for its treatment.To study and clarify the mechanism of DSC2 in tumor,to explore the specific targets of clinical examination and treatment can provide practical ideas for early treatment of disease.This article reviews the molecular structure of desmosome and DSC2,the relationship between DSC2 and tumor and its related molecular mechanism.关键词
桥粒/桥粒胶蛋白2/桥粒疾病/细胞黏附Key words
Desmosome/Desmocollin-2/Desmosome disease/Cell adhesion分类
医药卫生引用本文复制引用
魏盈盈,徐敏娟,谢水祥,王烈峰..桥粒胶蛋白2及其在肿瘤疾病中的研究进展[J].赣南医学院学报,2024,44(3):219-224,6.基金项目
国家自然科学基金资助项目(31860247) （31860247）
江西省自然科学基金重点项目(20202ACBL206003) （20202ACBL206003）
