赣南医学院学报2024，Vol.44Issue(3)：225-229,5.DOI:10.3969/j.issn.1001-5779.2024.03.002
自噬在乳腺癌中发挥作用的分子机制
The molecular mechanisms of autophagy in breast cancer
摘要
Abstract
The role of autophagy in breast cancer is complex.It may play the role of promoting or inhibiting through different molecular pathways depends on the stage of the breast cancer(BC)A few miRNAs promote or inhibit the progression of BC by up-regulating or down-regulating autophagy,and can also be used as a biomarker for the diagnosis and prognosis of patients with BC,as well as the potential therapeutic targets for BC.Beclin-1 protein inhibits or promotes the progression of BC by affecting the occurrence of autophagy.H19 lncRNA plays a key role in the progression,proliferation,metastasis,and treatment of BC through different molecular pathways.Up-regulating ERβ can promote autophagy of BC cells and inhibit their migration and invasion.Circular RNA circ-Dnmt1 inhibits the proliferation and survival of BC cells through the p53 and AUF1 pathways.KISS1 affects distant metastasis of BC through autophagy.In this paper,the molecular mechanisms of autophagy in breast cancer was reviewed.It will be helpful for the prevention and treatment of breast cancer.关键词
乳腺癌/自噬/分子机制Key words
Breast cancer/Autophgy/Molecular mechanism分类
医药卫生引用本文复制引用
王长松,范乃军,贠田,王亚喜..自噬在乳腺癌中发挥作用的分子机制[J].赣南医学院学报,2024,44(3):225-229,5.基金项目
河南省医学科技攻关计划资助项目(LHGJ20210823) （LHGJ20210823）
