摘要
Abstract
Objective:To investigate the effects of imipenem-cilastatin combined with moxifloxacin on liver and kidney function in elderly patients with severe pneumonia.Methods:A total of 100 elderly patients with severe pneumonia who were treated in our hospital from April 2020 to March 2023 were divided into control group(50 cases)and observation group(50 cases)according to the odd and even hospitalization numbers.The treatment plan was moxifloxacin alone in the control group,and imipenem-cilastatin combined with moxifloxacin in the observation group.The indexes of inflammatory factors,liver function and kidney function were compared between the two groups.Results:There was no significant difference in inflammatory factors between the two groups before treatment(P＞0.05).After treatment,serum inflammatory factors in 2 groups were significantly lower than before treatment(P＜0.05).In addition,C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in the observation group were all lower than those in the control group(P＜0.05).There was no significant difference in liver function between the two groups before treatment(P＞0.05).After treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TBil)in the 2 groups were treated.ALP and TBil were higher than before treatment(P＜0.05),but there was no statistical difference in liver function between the two groups(P＞0.05).There was no significant difference in renal function between the two groups before treatment(P＞0.05).Serum creatinine(Scr),urea nitrogen(BUN),uric acid(UA)and cystatin C(CysC)in 2 groups were all higher than those before treatment(P＜0.05).There was no statistical significance in renal function between the two groups(P＞0.05).The total effective rate of observation group was higher than that of control group(P＜0.05).Conclusion:In elderly patients with severe pneumonia,imipenem-cilastatin combined with moxifloxacin can effectively reduce patients'autoinflammatory response,and has little impact on liver and kidney function.关键词
亚胺培南-西司他丁/莫西沙星/肺炎/肝功能/肾功能/老年人Key words
Imipenem-cilastatin/Moxifloxacin/Pneumonia/Liver function/Kidney function/The aged分类
医药卫生
