高校化学工程学报2024，Vol.38Issue(2)：236-242,7.DOI:10.3969/j.issn.1003-9015.2024.02.008
聚醚功能化离子液体辅助不对称氢化合成D-泛解酸内酯
Synthesis of D-(-)-pantolactone via asymmetric hydrogenation assisted by a polyether-functionalized ionic liquid
摘要
Abstract
To solve the problem of recycling difficulty of chiral catalysts in asymmetric hydrogenation,rhodium-catalyzed homogeneous asymmetric hydrogenation of ketopantoyl lactone assisted by a polyether guanidinium ionic liquid was studied based on amino acid-and imidazolium-tagged chiral pyrrolidinodiphosphine ligands.The effects of rhodium precursor,diphosphine ligand structure,solvent effect and polyether ionic liquid doping on the catalytic activity and enantioselectivity were investigated.A homogeneous catalysis-liquid/solid separation system was constructed for the separation and recycling of the chiral catalyst using the optimal diphosphine ligand.The catalytic system showed high catalytic activity,enantioselectivity and long-term stability,and no significant decrease in catalytic performance was observed after 5 runs.This study provides the theoretical and experimental basis for the feasibility of asymmetric hydrogenation synthesis of D-pantolactone.关键词
D-泛解酸内酯/不对称氢化/离子液体/手性膦配体Key words
D-(-)-pantolactone/asymmetric hydrogenation/ionic liquid/chiral phosphine ligand分类
化学化工引用本文复制引用
尹迎春,崔菲菲,齐慧敏,金欣..聚醚功能化离子液体辅助不对称氢化合成D-泛解酸内酯[J].高校化学工程学报,2024,38(2):236-242,7.基金项目
青岛市基础研究项目(12-1-4-3-(6)-jch) （12-1-4-3-(6）
国家自然科学基金(21576144). （21576144）
