解放军医学院学报2024，Vol.45Issue(1)：12-17,6.DOI:10.12435/j.issn.2095-5227.2023.147
不同造模方法建立高尿酸血症动物模型的述评
Evaluation of different modeling methods to establish hyperuricemia animal models
摘要
Abstract
Hyperuricemia(HUA)is a metabolic disease caused by purine metabolism disorder.At present,the overall prevalence of HUA is increasing year by year,and the age of onset has become younger.HUA is an independent risk factor for a variety of cardiovascular risk events and related diseases.However,its pathogenesis has not been fully elucidated.Establishing a reliable animal model of hyperuricemia is the basis for studying its pathogenesis,related complications and therapeutic interventions.At present,the methods for establishing HUA animal models are complex and diverse,but there is no unified standard.Therefore,this paper discusses the species selection,the principle of modeling,and the preparation methods,and expounds the application value and potential problems of each modeling method,in order to provide reference for the establishment and replication of stable and reliable HUA animal models.关键词
高尿酸血症/动物模型/造模原理/高温高湿环境Key words
hyperuricemia/animal model/modeling principle/high temperature and high humidity environment分类
医药卫生引用本文复制引用
谭文彬,李佳..不同造模方法建立高尿酸血症动物模型的述评[J].解放军医学院学报,2024,45(1):12-17,6.基金项目
国家自然科学基金项目(81701913) （81701913）
