解放军医学院学报2024，Vol.45Issue(1)：72-77,6.DOI:10.12435/j.issn.2095-5227.2023.121
中老年男性体检人群良性前列腺增生关联因素研究
Factors associated with benign prostatic hyperplasia in middle-aged and elderly men undergoing physical examination
摘要
Abstract
Background Finding factors that associated with the development of benign prostatic hyperplasia(BPH)will be helpful in the early prevention of BPH.Objective To investigate the correlation between clinical indicators and prostate volume in middle-aged and elderly men undergoing physical examination,and find factors associated with the occurrence of BPH.Methods Clinical data about middle-aged and elderly men aged from 45 to 89 years who underwent health checkups in a health check center of a tertiary hospital from June 2021 to June 2023 were retrospectively analyzed,and total prostate volume(TPV)was used as a grouping criterion,with TPV>25 cm3 as the BPH group,and TPV≤25 cm3 as the healthy control group.Correlation analysis and multifactorial Logistic regression were used to analyze the risk factors and protective factors associated with the total volume of benign prostatic hyperplasia.Results Totally 6 732 cases were included,with 3 972 cases in the BPH group,and 2 760 cases in the healthy control group.Compared with the healthy control group,the BPH group had higher age(M[IQR]:56[51-60]years vs 53[49-58]years,P＜0.001),body mass index(BMI)(M[IQR]:26.41[24.64-28.36]kg/m2 vs 25.76[24.06-27.80]kg/m2,P＜0.001),fasting insulin(INS)(M[IQR]:10.67[7.27-15.53]mmol/L vs 10.25[6.90-14.93]mmol/L,P=0.005),total prostate specific antigen(tPSA)(M[IQR]:1.01[0.66-1.63]ng/L vs 0.75[0.51-1.10]ng/L,P<0.001),while the high-density lipoprotein-cholesterol(HDL-C)(M[IQR]:1.18[1.00-1.37]mmol/L vs 1.19[1.01-1.40]mmol/L,P=0.004)and fPSA/tPSA(M[IQR]:0.31[0.23-0.41]vs 0.32[0.24-0.42],P=0.016)were lower.Correlation analysis showed significant positive correlation between TPV and age(r=0.24,P<0.001),tPSA(r=0.33,P<0.001),fPSA(r=0.36,P<0.001);Multivariate Logistic regression analysis showed that the increase of age(OR=1.051,95%CI:1.042-1.060,P<0.001),BMI(OR=1.095,95%CI:1.076-1.116,P<0.001)and tPSA(OR=1.775,95%CI:1.647-1.973,P<0.001)were associated with higher risk of BPH,and men with higher HDL-C(OR=0.790,95%CI:0.665-0.945,P=0.009)had lower risk of BPH.Conclusion Age,BMI,tPSA and HDL-C are independently associated with occurrence of benign prostatic hyperplasia.关键词
中老年男性/良性前列腺增生/前列腺体积/体质量指数/高密度脂蛋白胆固醇Key words
middle-aged and elderly males/benign prostatic hyperplasia/prostate volume/body mass index/high-density lipoprotein cholesterol分类
医药卫生引用本文复制引用
逄瑷博,徐国纲,赵鑫,凌存保,田亚平,张春燕..中老年男性体检人群良性前列腺增生关联因素研究[J].解放军医学院学报,2024,45(1):72-77,6.基金项目
国家重点研发计划(2021YFC2009302) （2021YFC2009302）
