解放军医学院学报2024，Vol.45Issue(1)：100-104,封3,6.DOI:10.12435/j.issn.2095-5227.2023.139
血管内皮细胞调控血管平滑肌细胞表型的机制及其在动脉血管疾病中的作用研究进展
Research advances in regulation of vascular smooth muscle cell phenotypes by vascular endothelial cells in arterial vascular diseases
摘要
Abstract
Vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)are closely connected and affect each other functionally.VECs can regulate the phenotypic transition of VSMCs directly(Notch signaling pathway)or indirectly(cytokines,exosomes)in respond to external stimuli such as hypoxia,inflammation or abnormal mechanical forces and maintain vascular homeostasis.The abnormal process is an important cause of arterial vascular diseases such as atherosclerosis,aortic aneurysm and aortic dissection.In this paper,the mechanism of VECs regulating phenotypic transformation of VSMCs is reviewed.关键词
血管内皮细胞/血管平滑肌细胞/动脉血管疾病/表型转变/血管稳态Key words
vascular endothelial cell/vascular smooth muscle cell/arterial vascular disease/phenotype transformation/vascular homeostasis分类
医药卫生引用本文复制引用
高丹,张信信,韩骅,晏贤春..血管内皮细胞调控血管平滑肌细胞表型的机制及其在动脉血管疾病中的作用研究进展[J].解放军医学院学报,2024,45(1):100-104,封3,6.基金项目
国家自然科学基金项目(82103446 （）
32270966) （）
陕西省高校科协青年人才托举计划(20210301) （20210301）
