检验医学与临床2024，Vol.21Issue(9)：1214-1217,4.DOI:10.3969/j.issn.1672-9455.2024.09.006
中性粒细胞CD64指数对新生儿吸入性肺炎的诊断价值
Application value of neutrophil CD64 index in diagnosis of neonatal aspiration pneumonia
摘要
Abstract
Objective To investigate the value of neutrophil CD64(nCD64)index in the diagnosis of neo-natal aspiration pneumonia.Methods From July 2021 to July 2022,105 neonates with meconium or amniotic fluid aspiration during delivery in Guilin People's Hospital were selected for the study,and divided into 85 ca-ses with neonatal aspiration pneumonia infection(infection group)and 20 cases without aspiration pneumonia(control group)according to the clinical diagnosis.The levels of white blood cells(WBC),neutrophil percent-age(N%)and hypersensitive C-reactive protein(hs-CRP)were detected in the two groups,and the nCD64 in-dex was calculated.The efficacy of nCD64 index with WBC,N%and hs-CRP for the diagnosis of aspiration pneumonia in neonates was analyzed by plotting receiver operating characteristic(ROC)curve.Results The levels of nCD64 index,WBC and N%in the infection group were higher than those in the control group(P<0.05);the hs-CRP level in the infection group was higher than that in the control group,but the difference had no statistical significance(P>0.05).The results of the ROC curves showed that the area under the curve(AUC)for the diagnosis of aspiration pneumonia in newborn infants by nCD64 index alone was 0.882(95%CI:0.802-0.961),with a sensitivity and specificity of 88.2%and 75.0%,respectively;the AUC of N%for the diagnosis of aspiration pneumonia was 0.672(95%CI:0.537-0.806),with a sensitivity and specificity of 83.5%and 60.0%,respectively;the AUC of WBC for the diagnosis of aspiration pneumonia was 0.650(95%CI:0.516-0.783),with a sensitivity and specificity of 57.6%and 75.0%,respectively.Conclusion The nCD64 index has a high value in the diagnosis of neonatal aspiration pneumonia infection,which is worthy of clinical promotion.关键词
中性粒细胞CD64指数/新生儿吸入性肺炎/白细胞计数/超敏C反应蛋白/诊断Key words
neutrophil CD64 index/neonatal aspiration pneumonia/white blood cell differential count-ing/hypersensitive C-reactive protein/diagnosis分类
医药卫生引用本文复制引用
李娟,贺际芸,石青峰,李春亮,银娜秋,杨益锋,黄超宇,张雪琳,蒋文钦,黄嘉锦..中性粒细胞CD64指数对新生儿吸入性肺炎的诊断价值[J].检验医学与临床,2024,21(9):1214-1217,4.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20210910). （Z20210910）
